Allylphenols as a new class of human 15‐lipoxygenase‐1 inhibitors
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DOI: 10.1002/ddr.21749
Abstract: In this study, a series of mono‐ and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15‐lipoxygenase‐1 (15‐hLOX‐1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were… read more here.
Keywords: lipoxygenase; new class; class human; human lipoxygenase ... See more keywords
Novel 2-Thiouracil-5-Sulfonamide Derivatives: Design, Synthesis, Molecular Docking, and Biological Evaluation as Antioxidants with 15-LOX Inhibition
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DOI: 10.3390/molecules28041925
Abstract: New antioxidant agents are urgently required to combat oxidative stress, which is linked to the emergence of serious diseases. In an effort to discover potent antioxidant agents, a novel series of 2-thiouracil-5-sulfonamides (4–9) were designed… read more here.
Keywords: molecular docking; synthesis; lox inhibition; thiouracil sulfonamide ... See more keywords
The structural basis of effective LOX-1 inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0011
Abstract: Along with other scavenger receptors, splice variants of LOX-1 play an important role in modulating numerous subcellular mechanisms such as normal cell development, differentiation and growth in response to physiological stimuli. Thus, LOX-1 activity is… read more here.
Keywords: lox; effective lox; chemistry; structural basis ... See more keywords