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Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14039
Abstract: Lysyl oxidase‐like 2 (LOXL2) has shown to promote metastasis and poor prognosis in hepatocellular carcinoma (HCC). Also, we have previously reported that vasculogenic mimicry (VM) is associated with invasion, metastasis and poor survival in HCC…
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Keywords:
hepatocellular carcinoma;
hcc;
loxl2;
vasculogenic mimicry ... See more keywords
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Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-325564
Abstract: Objective The lysyl oxidase-like protein 2 (LOXL2) contributes to tumour progression and metastasis in different tumour entities, but its role in pancreatic ductal adenocarcinoma (PDAC) has not been evaluated in immunocompetent in vivo PDAC models.…
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Keywords:
mice;
loxl2;
tumour;
pancreatic ductal ... See more keywords
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Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2022-327430
Abstract: The role of the lysyl oxidase (LOX) family of enzymes, consisting of LOX and LOXlike (LOXL) proteins 1–4, is to catalyse the crosslinking of collagen and elastin in the extracellular matrix (ECM). Members of the…
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Keywords:
expression;
ecm;
progression;
loxl2 ... See more keywords
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Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4498
Abstract: Introduction: The lysyl oxidase family consists of 5 members and oxidizes specific lysine residues in biosynthetic collagen and elastin maturation. Lysyl oxidase like-2 (LOXL2) is elevated in oral cancer and promotes metastasis and correlates with…
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Keywords:
pxs s1c;
oral cancer;
loxl2;
cancer ... See more keywords
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Published in 2021 at "Cerebrovascular diseases"
DOI: 10.1159/000518526
Abstract: OBJECTIVES Angiotensin II (Ang II)-induced atrial fibrosis plays a vital role in the development of atrial fibrillation (AF). Lysyl oxidase-like 2 (LOXL2) plays an essential role in matrix remodeling and fibrogenesis, indicating it may involve…
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Keywords:
ang induced;
inhibitor;
fibrosis;
loxl2 ... See more keywords
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Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.778857
Abstract: Background: Pancreatic adenocarcinoma (PDAC) is the most aggressive among all solid malignancies with delayed disease detection and limited effective treatment. However, due to the intricate heterogeneity and exclusive tumor microenvironment (TME), the development of effective…
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Keywords:
immune infiltration;
expression;
pancreatic adenocarcinoma;
analysis ... See more keywords
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Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.569584
Abstract: Glioma is the most prevalent primary brain tumor in adults and has an extremely unfavorable prognosis. As a member of the lysyl oxidase (LOX) family, lysyl-oxidase-like-2 (LOXL2) is known to play different roles in different…
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Keywords:
glioma;
loxl2;
tmz;
upregulation gliomas ... See more keywords
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Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194798
Abstract: Background: The goal of this study was to determine if adenovirus-delivered LOXL2 protects against progressive knee osteoarthritis (OA), assess its specific mechanism of action; and determine if the overexpression of LOXL2 in transgenic mice can…
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Keywords:
protects progressive;
loxl2;
osteoarthritis;
expression ... See more keywords
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Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6452
Abstract: Colorectal cancer (CRC) is the third most common type of cancer. In the present study, the expression and intracellular localization of lysyl oxidase-like 2 (LOXL2) protein in CRC were examined. Quantitative polymerase chain reaction and…
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Keywords:
loxl2;
colorectal cancer;
lysyl oxidase;
expression ... See more keywords