Exploring breast cancer treatment paradigms: innovative design, molecular docking and dynamic simulation of LOXL2 inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Simulation"
DOI: 10.1080/08927022.2024.2333907
Abstract: ABSTRACT The impact of the LOXL2 enzyme on cell invasion and metastasis is significantly notable in breast cancer (BC), making it a promising therapeutic target in cancer drug discovery. Considering the diverse functions of lysyl… read more here.
Keywords: cancer; breast cancer; loxl2 inhibitors; loxl2 ... See more keywords
LOXL2 promotes vasculogenic mimicry and tumour aggressiveness in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14039
Abstract: Lysyl oxidase‐like 2 (LOXL2) has shown to promote metastasis and poor prognosis in hepatocellular carcinoma (HCC). Also, we have previously reported that vasculogenic mimicry (VM) is associated with invasion, metastasis and poor survival in HCC… read more here.
Keywords: hepatocellular carcinoma; hcc; loxl2; vasculogenic mimicry ... See more keywords
Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-325564
Abstract: Objective The lysyl oxidase-like protein 2 (LOXL2) contributes to tumour progression and metastasis in different tumour entities, but its role in pancreatic ductal adenocarcinoma (PDAC) has not been evaluated in immunocompetent in vivo PDAC models.… read more here.
Keywords: mice; loxl2; tumour; pancreatic ductal ... See more keywords
LOXL2 in pancreatic tumourigenesis: the complexity of tumour–stromal crosstalk exemplified
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2022-327430
Abstract: The role of the lysyl oxidase (LOX) family of enzymes, consisting of LOX and LOXlike (LOXL) proteins 1–4, is to catalyse the crosslinking of collagen and elastin in the extracellular matrix (ECM). Members of the… read more here.
Keywords: expression; ecm; progression; loxl2 ... See more keywords
Abstract 4498: Lysyl oxidase like-2 mediates tumor to stromal cell communication in oral cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4498
Abstract: Introduction: The lysyl oxidase family consists of 5 members and oxidizes specific lysine residues in biosynthetic collagen and elastin maturation. Lysyl oxidase like-2 (LOXL2) is elevated in oral cancer and promotes metastasis and correlates with… read more here.
Keywords: pxs s1c; oral cancer; loxl2; cancer ... See more keywords
LOXL2 Inhibitor Attenuates Angiotensin II-Induced Atrial Fibrosis and Vulnerability to Atrial Fibrillation through Inhibition of Transforming Growth Factor Beta-1 Smad2/3 Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebrovascular diseases"
DOI: 10.1159/000518526
Abstract: OBJECTIVES Angiotensin II (Ang II)-induced atrial fibrosis plays a vital role in the development of atrial fibrillation (AF). Lysyl oxidase-like 2 (LOXL2) plays an essential role in matrix remodeling and fibrogenesis, indicating it may involve… read more here.
Keywords: ang induced; inhibitor; fibrosis; loxl2 ... See more keywords
Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.778857
Abstract: Background: Pancreatic adenocarcinoma (PDAC) is the most aggressive among all solid malignancies with delayed disease detection and limited effective treatment. However, due to the intricate heterogeneity and exclusive tumor microenvironment (TME), the development of effective… read more here.
Keywords: immune infiltration; expression; pancreatic adenocarcinoma; analysis ... See more keywords
LOXL2 Upregulation in Gliomas Drives Tumorigenicity by Activating Autophagy to Promote TMZ Resistance and Trigger EMT
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.569584
Abstract: Glioma is the most prevalent primary brain tumor in adults and has an extremely unfavorable prognosis. As a member of the lysyl oxidase (LOX) family, lysyl-oxidase-like-2 (LOXL2) is known to play different roles in different… read more here.
Keywords: glioma; loxl2; tmz; upregulation gliomas ... See more keywords
To explore the potential of LOXL2 as a biomarker in glioma and construct a genomic integrated clinical prognostic model
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1602475
Abstract: Background Glioma is a common invasive tumor of the central nervous system, and its pathological features significantly impair the quality of life of patients, with high mortality risk and easy recurrence. For glioma Lysine Oxidase… read more here.
Keywords: biomarker glioma; prognostic model; loxl2; genomic integrated ... See more keywords
Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194798
Abstract: Background: The goal of this study was to determine if adenovirus-delivered LOXL2 protects against progressive knee osteoarthritis (OA), assess its specific mechanism of action; and determine if the overexpression of LOXL2 in transgenic mice can… read more here.
Keywords: protects progressive; loxl2; osteoarthritis; expression ... See more keywords
Lysyl oxidase-like 2 is highly expressed in colorectal cancer cells and promotes the development of colorectal cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6452
Abstract: Colorectal cancer (CRC) is the third most common type of cancer. In the present study, the expression and intracellular localization of lysyl oxidase-like 2 (LOXL2) protein in CRC were examined. Quantitative polymerase chain reaction and… read more here.
Keywords: loxl2; colorectal cancer; lysyl oxidase; expression ... See more keywords