Articles with "loxl3" as a keyword



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LOXL3‐promoted hepatocellular carcinoma progression via promotion of Snail1/USP4‐mediated epithelial‐mesenchymal transition

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Published in 2022 at "Environmental Toxicology"

DOI: 10.1002/tox.23617

Abstract: Lysyl‐oxidase‐like 3 (LOXL3) was reported to be essential in epithelial‐mesenchymal transition (EMT) of cancers. However, the role of LOXL3 in hepatocellular carcinoma (HCC) remained unclear. In this study, we explored clinical significance, biological functions, and… read more here.

Keywords: cell; hcc; usp4; snail1 ... See more keywords

Apoptosis Activation and Autophagy Inhibition of Chondrocytes by Leptin by the Upregulation of LOXL3 in Osteoarthritis Pathogenesis

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Published in 2022 at "Journal of Healthcare Engineering"

DOI: 10.1155/2022/4026128

Abstract: Background Osteoarthritis is one of the usual chronic musculoskeletal dysfunctions. It is one of the primary leading causes which leads to limitation of movement and absenteeism in the working adult population. Chondrocytes are the singlecellular-based… read more here.

Keywords: osteoarthritis; apoptosis; inhibition; loxl3 ... See more keywords
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Abstract 2605: LOXL3 knock out affects pathways which involve cytoskeleton regulation, proliferation and apoptosis in glioblastoma cells

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Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-2605

Abstract: Lysyl oxidase-like 3 (LOXL3), belonging to the lysyl oxidase family of copper-dependent amino oxidase, is responsible for the crosslinking of collagen and elastin. In tumors, the presence of LOXL3 has been associated with genomic stability,… read more here.

Keywords: cell; glioblastoma; proliferation; regulation ... See more keywords
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Progressive degeneration of the retina in Loxl3 mutant mouse model of Stickler syndrome.

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Published in 2023 at "Developmental biology"

DOI: 10.2139/ssrn.4207630

Abstract: Stickler syndrome is a multisystem collagenopathy with affected individuals exhibiting a high rate of ocular complications. Lysyl oxidase-like 3 (LOXL3) is a human disease gene candidate with a critical role in catalyzing collagen crosslinking. A… read more here.

Keywords: loxl3 mutant; loxl3; model stickler; mouse model ... See more keywords