Articles with "loxo 435" as a keyword



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Abstract CT119: A first-in-human phase 1 study of LOXO-435, a potent, highly isoform-selective FGFR3 inhibitor in advanced solid tumors with FGFR3 alterations (trial in progress)

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Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-ct119

Abstract: Background: Alterations in the fibroblast growth factor receptor 3 (FGFR3) have been identified as oncogenic drivers in several solid tumor malignancies, including urothelial carcinoma (UC). Available pan-FGFR inhibitors target all 4 isoforms of FGFR (FGFR1… read more here.

Keywords: phase; inhibitor; loxo 435; solid tumors ... See more keywords