Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement
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DOI: 10.1093/eurheartj/ehad093
Abstract: Abstract Aims Mosaic loss of Y chromosome (LOY) in blood cells is the most common acquired mutation, increases with age, and is related to cardiovascular disease. Loss of Y chromosome induces cardiac fibrosis in murine… read more here.
Keywords: loy; chromosome; aortic valve; loss chromosome ... See more keywords
Loss of chromosome Y in blood, but not in brain, of suicide completers
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DOI: 10.1371/journal.pone.0190667
Abstract: Men have a higher rate of completed suicide than women, which suggests that sex chromosome abnormalities may be related to the pathophysiology of suicide. Recent studies have found an aberrant loss of chromosome Y (LOY)… read more here.
Keywords: suicide completers; loy; blood; brain ... See more keywords
Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells
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DOI: 10.3324/haematol.2019.240689
Abstract: Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in hematopoietic cells in men. However, due to the high prevalence of LOY as the sole cytogenetic finding in the… read more here.
Keywords: genomic alterations; cytogenetic finding; loy; bone ... See more keywords