Lysophosphatidic acid induces the crosstalk between the endovascular human trophoblast and endothelial cells in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27358
Abstract: Spiral artery remodeling at the maternal–fetal interface is crucial for successful pregnancy and requires the interaction between the first trimester trophoblast and the endothelial cells of the maternal vessels. However, the precise mechanism of this… read more here.
Keywords: lysophosphatidic acid; endothelial cells; lpa; trophoblast endothelial ... See more keywords
Fate of the Left Pulmonary Artery and Thoracic Aorta After Transcatheter Patent Ductus Arteriosus Closure in Low Birth Weight Premature Infants
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DOI: 10.1007/s00246-020-02523-8
Abstract: Transcatheter patent ductus arteriosus closure (TCPC) is an emerging treatment for low birth weight extremely premature neonates (EPNs). Left pulmonary artery (LPA) and descending aorta (DAO) obstruction are described device-related complications, however, data on mid-… read more here.
Keywords: patent ductus; weight; arteriosus closure; transcatheter patent ... See more keywords
Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.11.023
Abstract: Cancer-associated fibroblasts (CAFs) play a critical role in cancer progression, metastasis, and therapy resistance. Molecular events that confer CAF-phenotype to predecessor-cells are not fully understood. We demonstrate here that the ovarian cancer cell-conditioned medium (OCC-CM)… read more here.
Keywords: glycolytic shift; ovarian cancer; lpa; cancer cell ... See more keywords
Oxidative stress mediated myocardial lysophosphatidic acid signaling
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.206
Abstract: The bioactive lysophosphatidic acid (LPA) plays a well-known role in atherosclerotic disease, whereas, its role in myocardial function remains virtually unexplored. Following acute myocardial infarction, serum LPA concentration rises by six-fold over control human subjects,… read more here.
Keywords: autotaxin; lpa; lpp3; lysophosphatidic acid ... See more keywords
Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2021.05.037
Abstract: BACKGROUND Lipoprotein(a) (Lp(a)) concentrations are a major independent risk factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up to 70% of the LPA coding sequence is located in the… read more here.
Keywords: lipoprotein concentrations; cad; disease; coronary artery ... See more keywords
Differential effects of thymoquinone on lysophosphatidic acid-induced oncogenic pathways in ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2020.04.001
Abstract: Thymoquinone, a therapeutic phytochemical derived from Nigella sativa, has been shown to have a potent anticancer activity. However, it has been identified that the tumor microenvironment (TME) can attenuate the anticancer effects of thymoquinone (TQ)… read more here.
Keywords: pathways ovarian; ovarian cancer; lpa; cancer cells ... See more keywords
Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.11.010
Abstract: Lysophosphatidic acid (LPA) is known to regulate various biological responses by binding to LPA receptors. The serum level of LPA is elevated in diabetes, but the involvement of LPA in the development of diabetes and… read more here.
Keywords: lpa receptor; expression; lpa; diabetic nephropathy ... See more keywords
Hemodynamics in a bidirectional Glenn Shunt supplemented with a modified Blalock-Taussig shunt: Computational fluid dynamics assessment
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Pediatric Cardiology"
DOI: 10.1016/j.ppedcard.2020.101256
Abstract: Abstract The bidirectional Glenn Shunt (BGS), superior vena cava (SVC) to right pulmonary artery (RPA) is occasionally supplemented with a left modified Blalock-Taussig shunt (mBTS) when PA growth is inadequate. Little is known about hemodynamics… read more here.
Keywords: mmhg; bidirectional glenn; rpa; lpa ... See more keywords
Impact of Crossing Parent and Environment on the Metabolite Profiles of Progenies Generated from a Low Phytic Acid Rice ( Oryza sativa L.) Mutant.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b06696
Abstract: The low phytic acid ( lpa) rice mutant Os-lpa-MH86-1, exhibiting a mutation-induced metabolite signature (i.e., increased levels of sugars, sugar alcohols, amino acids, phytosterols, and biogenic amines), was crossed with two commercial wild-type cultivars. The… read more here.
Keywords: phytic acid; rice; low phytic; metabolite profiles ... See more keywords
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
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DOI: 10.1038/s41467-021-20986-y
Abstract: Dynamic assembly and disassembly of primary cilia controls embryonic development and tissue homeostasis. Dysregulation of ciliogenesis causes human developmental diseases termed ciliopathies. Cell-intrinsic regulatory mechanisms of cilia disassembly have been well-studied. The extracellular cues controlling… read more here.
Keywords: cilia disassembly; initiate cilia; neurogenesis; disassembly promote ... See more keywords
Signalling by lysophosphatidate and its health implications.
Sign Up to like & getrecommendations! Published in 2020 at "Essays in biochemistry"
DOI: 10.1042/ebc20190088
Abstract: Extracellular lysophosphatidate (LPA) signalling is regulated by the balance of LPA formation by autotaxin (ATX) versus LPA degradation by lipid phosphate phosphatases (LPP) and by the relative expressions of six G-protein-coupled LPA receptors. These receptors… read more here.
Keywords: lysophosphatidate health; health implications; lpa signalling; radiation induced ... See more keywords