LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation
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DOI: 10.1073/pnas.2118816119
Abstract: Significance Cancers and chronic infectious pathogens often evade immune-mediated elimination by suppressing T cell function via engaging inhibitory receptors expressed on T cells. The phospholipid lysophosphatidic acid (LPA) is often increased systemically from basal concentrations… read more here.
Keywords: immune synapse; function; lpa suppresses; cell function ... See more keywords