Hypertrophy and Fibrosis of the Ligamentum Flavum in Lumbar Spinal Stenosis is Associated With Increased Expression of LPA and LPAR1
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Spine Surgery"
DOI: 10.1097/bsd.0000000000000048
Abstract: Study Design: Histologic, immunohistochemical (IHC), and enzyme-linked immunosorbent assay analysis of the human ligamentum flavum (LF). Objective: The purpose of this study was to determine the level of expression of lysophosphatidic acid (LPA) in the… read more here.
Keywords: hypertrophy fibrosis; lpar1; expression; lpa ... See more keywords
LPAR1, Correlated With Immune Infiltrates, Is a Potential Prognostic Biomarker in Prostate Cancer
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DOI: 10.3389/fonc.2020.00846
Abstract: Prostate cancer is a common malignancy in men worldwide. Lysophosphatidic acid receptor 1 (LPAR1) is a critical gene and it mediates diverse biologic functions in tumor. However, the correlation between LPAR1 and prognosis in prostate… read more here.
Keywords: immune infiltrates; correlated immune; prostate cancer; cancer ... See more keywords
Reduction of LPAR1 Expression in Neuroblastoma Promotes Tumor Cell Migration
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DOI: 10.3390/cancers14143346
Abstract: Simple Summary The tumor metastasis in the bone marrow or other organs in high-risk neuroblastoma patients is a serious problem to tackle and strongly impairs the survival of patients. Novel and effective targets for the… read more here.
Keywords: lpar1; expression; neuroblastoma; migration ... See more keywords
Lysophosphatidic Acid Promotes Epithelial–Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy
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DOI: 10.3390/ijms231810497
Abstract: The epithelial–mesenchymal transition (EMT) is a differentiation process associated with fibrogenesis in diabetic nephropathy (DN). Lysophosphatidic acid (LPA) is a small, naturally occurring glycerophospholipid implicated in the pathogenesis of DN. In this study, we investigated… read more here.
Keywords: lpar1; expression; klf5; treatment ... See more keywords