Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14291
Abstract: Lysophosphatidylcholine (LPC), the active metabolite of palmitate, triggers hepatocyte death by activating endoplasmic reticulum stress and JNK signalling‐mediated lipoapoptosis. However, LPC‐induced cytotoxicity in hepatocytes is not well understood. Here, we found for the first time… read more here.
Keywords: adhesion; cell; anoikis hepatocytes; cell adhesion ... See more keywords
VEGF- and PDGF-dependent proliferation of oligodendrocyte progenitor cells in the medulla oblongata after LPC-induced focal demyelination
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2019.04.016
Abstract: The myelin sheath is critical in maintaining normal functions of the adult central nervous system (CNS) and the loss of the myelin sheath results in various neurological diseases. Although remyelination is the intrinsic repair system… read more here.
Keywords: lpc induced; demyelination; medulla oblongata; proliferation ... See more keywords
Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.8300
Abstract: The role of resveratrol (trans-3,5,4'-trihydroxystilbene; RES) in lysophosphatidylcholine (LPC)‑induced injury and inflammation in endothelial cells (regarded as an early event in arteriosclerosis) is unclear. The present study investigated whether RES reduces lactate dehydrogenase (LDH) activity… read more here.
Keywords: lpc; inflammation; induced damage; lpc induced ... See more keywords