Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000375
Abstract: BACKGROUND AIMS Nonalcoholic steatohepatitis (NASH), characterized by inflammation and fibrosis, is emerging as a leading etiology of hepatocellular carcinoma (HCC). Lipidomics analyses in the liver have shown that the levels of polyunsaturated phosphatidylcholine (PC) are… read more here.
Keywords: lpcat3; mitochondrial homeostasis; membrane; phospholipid remodeling ... See more keywords
USF2 exacerbates sepsis-induced acute kidney injury and ferroptosis through LPCAT3-mediated NRF2/HO-1/GPX4 pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Shock"
DOI: 10.1097/shk.0000000000002588
Abstract: ABSTRACT Background: Sepsis-acute kidney injury (AKI) is a common complication in critically ill patients with a very high mortality rate. Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is crucial in lipid metabolism; however, its role in the pathogenesis… read more here.
Keywords: sepsis aki; lpcat3; nrf2 gpx4; hk2 cells ... See more keywords