Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01537-3
Abstract: Latrophilin-3 (Lphn3; also known as ADGRL3) is a member of the adhesion G Protein Coupled Receptor subfamily, which participates in the stabilization and maintenance of neuronal networks by mediating intercellular adhesion through heterophilic interactions with… read more here.
Keywords: selective signaling; lphn3; pathogenicity; adhesion ... See more keywords
Alternative splicing of latrophilin-3 controls synapse formation
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DOI: 10.1038/s41586-023-06913-9
Abstract: The assembly and specification of synapses in the brain is incompletely understood1–3. Latrophilin-3 (encoded by Adgrl3, also known as Lphn3)—a postsynaptic adhesion G-protein-coupled receptor—mediates synapse formation in the hippocampus4 but the mechanisms involved remain unclear.… read more here.
Keywords: postsynaptic protein; lphn3; alternative splicing; synapse formation ... See more keywords
An assessment of executive function in two different rat models of attention‐deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.1111/gbb.12767
Abstract: Attention‐deficit/hyperactivity disorder (ADHD) a common neurodevelopmental disorder of childhood and often comorbid with other externalizing disorders (EDs). There is evidence that externalizing behaviors share a common genetic etiology. Recently, a genome‐wide, multigenerational sample linked variants… read more here.
Keywords: spontaneously hypertensive; disorder; deficit hyperactivity; hyperactivity disorder ... See more keywords