Identification and functional characterization of a novel heterozygous missense variant in the LPL associated with recurrent hypertriglyceridemia‐induced acute pancreatitis in pregnancy
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1048
Abstract: Acute pancreatitis in pregnancy (APIP) is a life‐threatening disease for both mother and fetus. To date, only three patients with recurrent hypertriglyceridemia‐induced APIP (HTG‐APIP) have been reported to carry rare variants in the lipoprotein lipase… read more here.
Keywords: acute pancreatitis; lpl; pancreatitis pregnancy; hypertriglyceridemia induced ... See more keywords
Photophysical tuning of small-molecule-doped organic crystals with long-persistent luminescence by variation of dopants
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2021.109501
Abstract: Abstract Design of host-guest structure has been an important direction in the development of organic long-persistent luminescence (LPL) materials, which have challenged traditional inorganic materials in some applications, such as anti-counterfeiting and bioimaging. The charge… read more here.
Keywords: crystals long; lpl; long persistent; charge ... See more keywords
Increased plasma lipoprotein lipase activity in males with autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2020 at "Research in Autism Spectrum Disorders"
DOI: 10.1016/j.rasd.2020.101630
Abstract: Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex genetics, characterized by impaired social communication and repetitive behaviors and interests. The involvement of lipid metabolism in ASD pathophysiology has been demonstrated in… read more here.
Keywords: lpl; disorder; activity; lpl activity ... See more keywords
Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b00945
Abstract: Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipoproteins. Whereas most identified mutations in the LPL gene are deleterious, one mutation, LPLS447X, causes a gain of function. This mutation truncates two… read more here.
Keywords: lipoprotein lipase; lpls447x; lipoprotein uptake; lpl ... See more keywords
Tumor suppressor ZHX2 inhibits NAFLD–HCC progression via blocking LPL-mediated lipid uptake
Sign Up to like & getrecommendations! Published in 2019 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-019-0453-z
Abstract: Non-alcoholic fatty liver disease (NAFLD) leads to hepatocellular carcinoma (HCC). However, the underlying mechanism remains largely unclear. Here, we investigated the role of the tumor suppressor Zinc fingers and homeoboxes 2 (ZHX2) in the progression… read more here.
Keywords: hcc; lpl; zhx2; progression ... See more keywords
Lipoprotein lipase is active as a monomer
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1900983116
Abstract: Significance Lipoprotein lipase (LPL) plays a central role in plasma lipid metabolism, hydrolyzing the triglycerides in lipoproteins and releasing fatty acid nutrients for vital tissues. LPL is synthesized by adipocytes and myocytes and secreted into… read more here.
Keywords: size; lipoprotein lipase; salt peak; lpl ... See more keywords
Plasma concentrations of apolipoproteins C3 and C2 do not explain differences in insulin-stimulated endothelial-bound lipoprotein lipase activity in insulin resistant humans
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733491
Abstract: Elevated circulating triglycerides (i.e., dyslipidemia) is a hallmark of insulin resistance and is generally caused by decrease in lipoprotein lipase (LPL) activity. LPL hydrolyzes triglycerides (TG) into free fatty acids in plasma for use and/or… read more here.
Keywords: insulin resistant; lpl; physiology; plasma ... See more keywords
Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.96783
Abstract: In mammals, GPIHBP1 is absolutely essential for transporting lipoprotein lipase (LPL) to the lumen of capillaries, where it hydrolyzes the triglycerides in triglyceride-rich lipoproteins. In all lower vertebrate species (e.g., birds, amphibians, reptiles, fish), a… read more here.
Keywords: reaches capillary; lumen chickens; lpl; gpihbp1 ... See more keywords
Severely impaired activity of lipoprotein lipase Arg243His is partially ameliorated by emulsifying phospholipids in in vitro triolein hydrolysis analysis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical Biochemistry"
DOI: 10.1177/0004563217693258
Abstract: Background We investigated the in vitro effects of various phospholipids as emulsifiers on the hydrolysing activities of lipoprotein lipase (LPL) Arg243His against triolein as substrate. LPL Arg243His, identified in a patient with hyperchylomicronaemia, displays severely… read more here.
Keywords: triolein hydrolysis; activity; lpl; mol ... See more keywords
On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity
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DOI: 10.1194/jlr.m088807
Abstract: Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma triglyceride metabolism. It was previously reported that ANGPTL8 requires another member of the ANGPTL family, ANGPTL3, to act on LPL. ANGPTL3,… read more here.
Keywords: lpl; activity; like protein; mechanism angiopoietin ... See more keywords
OR21-3 Familial Chylomicronemia Syndrome: Distinguishing the Rare Among the Common in Adults for Appropriate Management
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-or21-3
Abstract: Abstract Background: Hypertriglyceridemia (HTG) is common, but familial chylomicronemia syndrome (FCS) is a very rare cause of severe HTG, associated with pancreatitis, which can be fatal. It is due to impaired lipoprotein lipase (LPL) function,… read more here.
Keywords: pancreatitis; lpl; htg; familial chylomicronemia ... See more keywords