Apolipoprotein C-II mimetic peptide is an efficient activator of lipoprotein lipase in human plasma as studied by a calorimetric approach.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.130
Abstract: Elevated plasma triglyceride (TG) levels are associated with higher risk of atherosclerotic cardiovascular disease. One way to reduce plasma TG is to increase the activity of lipoprotein lipase (LPL), the rate limiting enzyme in plasma… read more here.
Keywords: peptide; plasma; 18a cii; lpl activity ... See more keywords
New rare genetic variants of LMF1 gene identified in severe hypertriglyceridemia.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2018.06.018
Abstract: BACKGROUND The LMF1 (lipase maturation factor 1) gene encodes a protein involved in lipoprotein lipase and hepatic lipase maturation. Homozygous mutations in LMF1 leading to severe hypertriglyceridemia (SHTG) are rare in the literature. A few… read more here.
Keywords: severe hypertriglyceridemia; lpl activity; gene; lmf1 ... See more keywords
Simple and rapid real-time monitoring of LPL activity in vitro
Sign Up to like & getrecommendations! Published in 2020 at "MethodsX"
DOI: 10.1016/j.mex.2020.100865
Abstract: Since elevated plasma triglycerides are an independent risk factor for cardiovascular diseases, lipoprotein lipase (LPL) is an interesting target for drug development. However, investigation of LPL remains challenging, as most of the commercially available assays… read more here.
Keywords: lpl activity; activity; real time; simple rapid ... See more keywords
Increased plasma lipoprotein lipase activity in males with autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2020 at "Research in Autism Spectrum Disorders"
DOI: 10.1016/j.rasd.2020.101630
Abstract: Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex genetics, characterized by impaired social communication and repetitive behaviors and interests. The involvement of lipid metabolism in ASD pathophysiology has been demonstrated in… read more here.
Keywords: lpl; disorder; activity; lpl activity ... See more keywords
Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214081120
Abstract: Triglyceride (TG) metabolism is highly regulated by angiopoietin-like protein (ANGPTL) family members [Y. Q. Chen et al., J. Lipid Res. 61, 1203-1220 (2020)]. During feeding, ANGPTL8 forms complexes with the fibrinogen-like domain-containing protein ANGPTL4 in adipose tissue… read more here.
Keywords: lpl activity; plasminogen; angptl4; plasmin ... See more keywords