Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
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DOI: 10.1038/s41467-020-14655-9
Abstract: Lipopolysaccharide (LPS) O-antigen (O-Ag) is known to limit antibody binding to surface antigens, although the relationship between antibody, O-Ag and other outer-membrane antigens is poorly understood. Here we report, immunization with the trimeric porin OmpD… read more here.
Keywords: surface; antibody; outer membrane; lps antigen ... See more keywords
Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization
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DOI: 10.1038/s41598-024-71487-z
Abstract: The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part of our innate immune response… read more here.
Keywords: lps antigen; complement mediated; antigen prevents; mediated killing ... See more keywords