Metabolism drives monocytes during inflammation: What we do and do not know
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ce1118-448r
Abstract: The quest for discovering novel therapeutics to treat acute inflammatory conditions such as sepsis has been a significant challenge for scientists and physicians. Despite promising discoveries using animal models, innumerable clinical trials have failed to… read more here.
Keywords: activation; sepsis; biology; metabolic intermediates ... See more keywords
Reduced inhibition underlies early life LPS exposure induced-cognitive impairment: Prevention by environmental enrichment.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108724
Abstract: Early life immune activation has negative effects on the development of central nervous system and cognitive function, yet the underlying mechanism remains unclear. Increasing evidence has demonstrated that inflammation induces changes in microglia morphology, which… read more here.
Keywords: early life; life lps; exposure induced; cognitive impairment ... See more keywords
Prenatal Lipopolysaccharide Exposure Alters Hepatic Drug-Metabolizing Enzyme Expression in Mouse Offspring via Histone Modifications
Sign Up to like & getrecommendations! Published in 2023 at "Toxics"
DOI: 10.3390/toxics11010082
Abstract: Inflammation is a major regulator of drug-metabolizing enzymes (DMEs), therefore contributing to the interindividual variability of drug effects. However, whether prenatal inflammation affects DMEs expression in offspring remains obscure. This study investigated the effects of… read more here.
Keywords: prenatal lipopolysaccharide; expression; lps exposure; drug metabolizing ... See more keywords