MyD88 and not TRIF knockout is sufficient to abolish LPS‐induced inflammatory responses in bone‐derived macrophages
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14616
Abstract: Macrophages play an important role in the response to infection and/or repair of injury in tissues. To examine the NF‐κB pathway in response to an inflammatory stimulus, we used wild‐type bone‐marrow‐derived macrophages (BMDMs) or BMDMs… read more here.
Keywords: trif; derived macrophages; myd88 trif; knockout ... See more keywords
Chemical inducer of regucalcin attenuates lipopolysaccharide-induced inflammatory responses in pancreatic MIN6 β-cells and RAW264.7 macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13321
Abstract: We previously isolated derrisfolin A, a novel rotenoid derivative, from the stems of Derris trifoliata Lour. (Leguminosae). Here, we report that derrisfolin A induces the expression of endogenous regucalcin (RGN) protein in both pancreatic MIN6… read more here.
Keywords: raw264 macrophages; lps induced; min6 cells; cells raw264 ... See more keywords
Overexpression of interleukin‐10 in engineered macrophages protects endothelial cells against LPS‐induced injury in vitro
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DOI: 10.1002/2211-5463.13365
Abstract: Endothelial dysfunction is a primary pathophysiological change in sepsis. Macrophages are known to interact with vascular endothelial cells during the development of sepsis. Recently, drug delivery based on engineered macrophages was reported as an alternative… read more here.
Keywords: engineered macrophages; endothelial cells; lps induced; cells lps ... See more keywords
Long non‐coding RNA MALAT1 sponges miR‐149 to promote inflammatory responses of LPS‐induced acute lung injury by targeting MyD88
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11235
Abstract: Acute lung injury (ALI) caused by sepsis occurs early and the condition is severe, and is also an important reason for accelerating the death of patients. Increasing evidence has identified long non‐coding RNA (lncRNA) metastasis… read more here.
Keywords: lung injury; lps induced; mir 149; malat1 ... See more keywords
L6H9 attenuates LPS‐induced acute lung injury in rats through targeting MD2
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21607
Abstract: Acute lung injury (ALI) is a clinical syndrome characterized by respiratory failure and acute inflammatory response. Myeloid differentiation protein 2 (MD2) has been reported to play a pivotal role in the recognition of LPS and… read more here.
Keywords: md2; lps induced; acute lung; attenuates lps ... See more keywords
Mycobacterium tuberculosis glycolipoprotein LprG inhibits inflammation through NF‐κB signaling of ERK1/2 and JNK in LPS‐induced murine macrophage cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30220
Abstract: Mycobacterium tuberoculosis (Mtb) is a contagious pathogen that causes human tuberculosis (TB). TB is a major global health threat that causes 9.6 million illnesses and 1.5 million deaths per year. Recent studies have suggested Mtb‐secreted… read more here.
Keywords: inflammation; lprg inhibits; tuberculosis; lprg ... See more keywords
Mig6 reduces inflammatory mediators production by regulating the activation of EGFR in LPS‐induced endotoxemia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26488
Abstract: Epithelial growth factor receptor (EGFR), a tyrosine kinase receptor, plays a critical role in lipopolysaccharide (LPS)‐induced endotoxemia. Meanwhile, EGFR signaling is regulated by multiple feedback regulators, including mitogen‐inducible gene 6 protein (Mig6). However, as an… read more here.
Keywords: lps induced; production; induced endotoxemia; activation ... See more keywords
RNF144B inhibits LPS‐induced inflammatory responses via binding TBK1
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2a0819-055r
Abstract: Innate immune responses need to be precisely controlled to avoid prolonged inflammation and prevent unwanted damage to the host. Here, we report that RNF144B responded dynamically to LPS stimulation and negatively regulated LPS‐induced inflammation. We… read more here.
Keywords: rnf144b inhibits; inhibits lps; tbk1; induced inflammatory ... See more keywords
Reactive oxygen species stimulated pulmonary epithelial cells mediate the alveolar recruitment of FasL+ killer B cells in LPS‐induced acute lung injuries
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0218-075r
Abstract: Reactive oxygen species (ROS) are electrophilic chemical species produced from incomplete oxidation. They have long been known as aggressive molecules that lead to direct tissue and cellular damage. Recent studies have reconsidered ROS as second… read more here.
Keywords: reactive oxygen; epithelial cells; lps induced; oxygen species ... See more keywords
Sophoridine inhibits endotoxin‐induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation
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DOI: 10.1002/jlb.3ma0322-428r
Abstract: Acute lung injury (ALI) is characterized by uncontrolled inflammation, which can lead to respiratory distress syndrome and cause patient death. In this study, we sought to determine the role of sophoridine, a compound purified from… read more here.
Keywords: acute lung; inflammation; lung injury; sophoridine ... See more keywords
A high‐calorie diet aggravates LPS‐induced pneumonia by disturbing the gut microbiota and Th17/Treg balance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0322-458rr
Abstract: The intestinal flora plays an important role in the inflammatory response to the systemic or local infections in the host. A high‐calorie diet has been shown to aggravate pneumonia and delay recovery, especially in children.… read more here.
Keywords: microbiota; th17 treg; high calorie; lps induced ... See more keywords