Cerebral Metabolic Changes Related to Oxidative Metabolism in a Model of Bacterial Meningitis Induced by Lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2018 at "Neurocritical Care"
DOI: 10.1007/s12028-018-0509-9
Abstract: BackgroundCerebral mitochondrial dysfunction is prominent in the pathophysiology of severe bacterial meningitis. In the present study, we hypothesize that the metabolic changes seen after intracisternal lipopolysaccharide (LPS) injection in a piglet model of meningitis is… read more here.
Keywords: meningitis; lps injection; metabolic changes; oxidative metabolism ... See more keywords
Synaptic structure and alterations in the hippocampus in neonatal rats exposed to lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134364
Abstract: Synaptic structure integrity plays a key role in learning and memory. Previous studies have shown that there is cognitive dysfunction in septic neonates in later life. In this study, intraperitoneal injection of lipopolysaccharide (LPS) in… read more here.
Keywords: lps injection; synaptic structure; hippocampus; expression ... See more keywords
Widespread time-dependent changes in tissue cytokine concentrations in brain regions during the acute phase of endotoxemia in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.10.006
Abstract: Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction induced by the systemic response to infection in septic patients. In the present study, we modeled SAE by administering lipopolysaccharide (LPS) intraperitoneally to mice at a concentration… read more here.
Keywords: acute phase; lps injection; endotoxemia; brain regions ... See more keywords
Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.109931
Abstract: The decrease of microglia in the hippocampus is a novel mechanism for depression onset. Reversal of this decrease can ameliorate stress-induced depression-like behaviors in rodents. However, the property of this therapeutic strategy remains unclear. We… read more here.
Keywords: lps injection; depression; administration; chronic unpredictable ... See more keywords
Scutellarin alleviates lipopolysaccharide-provoked septic nephrotoxicity via attenuation of inflammatory and oxidative events and mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2141644
Abstract: Abstract Background Sepsis-associated acute kidney injury (AKI) is highlighted by high incidence of mortality and morbidity. Scutellarin is a flavone extracted from certain medicinal plants with anti-inflammatory and anti-oxidative properties. This research study was done… read more here.
Keywords: scutellarin alleviates; factor; scutellarin; gene expression ... See more keywords
PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01804-6
Abstract: Background Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo… read more here.
Keywords: lps injection; pet; cyclooxygenase; cox ... See more keywords
Cardiorespiratory Alterations in a Newborn Ovine Model of Systemic Inflammation Induced by Lipopolysaccharide Injection
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00585
Abstract: Although it is well known that neonatal sepsis can induce important alterations in cardiorespiratory control, their detailed early features and the mechanisms involved remain poorly understood. As a first step in resolving this issue, the… read more here.
Keywords: lps injection; inflammation; model systemic; injection ... See more keywords