In vitro sepsis upregulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16088
Abstract: BACKGROUND AND PURPOSE In animal models of sepsis, increased activation of the Nociceptin/Orphanin FQ (N/OFQ) receptor NOP is associated with mortality and NOP antagonists improved survival. We have explored the role of the N/OFQ-NOP system… read more here.
Keywords: sepsis; lps pepg; expression; ofq ... See more keywords
In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0274080
Abstract: Sepsis is a dysregulated host response to infection that can cause widespread effects on other organs including cardiovascular depression, hypotension and organ failure. The receptor for Nociceptin/Orphanin FQ (N/OFQ), NOP is expressed on immune cells… read more here.
Keywords: sepsis; vitro sepsis; lps pepg; nociceptin orphanin ... See more keywords