Lipopolysaccharide Preconditioning Restricts Microglial Overactivation and Alleviates Inflammation-Induced Depressive-like Behavior in Mice
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DOI: 10.3390/brainsci13040549
Abstract: Overactive microglia and severe neuroinflammation play crucial roles in the development of major depressive disorder. Preconditioning with lipopolysaccharide (LPS) provides protection against severe neuroinflammation. However, administering high doses of LPS to mice triggers depressive symptoms.… read more here.
Keywords: inflammation; dose lps; lps preconditioning; like behavior ... See more keywords