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Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.07.001
Abstract: Synovial fibroblasts (SF) drive inflammation and joint destruction in chronic arthritis. Here we show that SF possess a distinct type of LPS tolerance compared to macrophages and other types of fibroblasts. In SF and dermal…
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Keywords:
type;
lps tolerance;
specific lps;
gene promoters ... See more keywords
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Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00955-7
Abstract: Following re-exposure to lipopolysaccharide (LPS), macrophages exhibit an immunosuppressive state known as LPS tolerance, which is characterized by repressed proinflammatory cytokine production. LPS-induced tolerance in macrophages is mediated in part by epigenetic changes. Carboplatin, an…
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Keywords:
epigenetic modifications;
tolerance;
lps tolerant;
lps tolerance ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031676
Abstract: Because both endotoxemia and gut dysbiosis post-splenectomy might be associated with systemic infection, the susceptibility against infection was tested by dextran sulfate solution (DSS)-induced colitis and lipopolysaccharide (LPS) injection models in splenectomy mice with macrophage…
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Keywords:
splenectomy;
gut;
lps tolerance;
splenectomy mice ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065363
Abstract: The responses of macrophages to lipopolysaccharide (LPS) might determine the direction of clinical manifestations of sepsis, which is the immune response against severe infection. Meanwhile, the enhancer of zeste homologue 2 (Ezh2), a histone lysine…
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Keywords:
ezh2 null;
ezh2;
lps tolerance;
severe lps ... See more keywords