The epigenetic architecture at gene promoters determines cell type-specific LPS tolerance.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.07.001
Abstract: Synovial fibroblasts (SF) drive inflammation and joint destruction in chronic arthritis. Here we show that SF possess a distinct type of LPS tolerance compared to macrophages and other types of fibroblasts. In SF and dermal… read more here.
Keywords: type; lps tolerance; specific lps; gene promoters ... See more keywords
The chemotherapeutic drug carboplatin affects macrophage responses to LPS and LPS tolerance via epigenetic modifications
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DOI: 10.1038/s41598-021-00955-7
Abstract: Following re-exposure to lipopolysaccharide (LPS), macrophages exhibit an immunosuppressive state known as LPS tolerance, which is characterized by repressed proinflammatory cytokine production. LPS-induced tolerance in macrophages is mediated in part by epigenetic changes. Carboplatin, an… read more here.
Keywords: epigenetic modifications; tolerance; lps tolerant; lps tolerance ... See more keywords
Enhanced Bacteremia in Dextran Sulfate-Induced Colitis in Splenectomy Mice Correlates with Gut Dysbiosis and LPS Tolerance
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DOI: 10.3390/ijms23031676
Abstract: Because both endotoxemia and gut dysbiosis post-splenectomy might be associated with systemic infection, the susceptibility against infection was tested by dextran sulfate solution (DSS)-induced colitis and lipopolysaccharide (LPS) injection models in splenectomy mice with macrophage… read more here.
Keywords: splenectomy; gut; lps tolerance; splenectomy mice ... See more keywords
The Regulatory Roles of Ezh2 in Response to Lipopolysaccharide (LPS) in Macrophages and Mice with Conditional Ezh2 Deletion with LysM-Cre System
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DOI: 10.3390/ijms24065363
Abstract: The responses of macrophages to lipopolysaccharide (LPS) might determine the direction of clinical manifestations of sepsis, which is the immune response against severe infection. Meanwhile, the enhancer of zeste homologue 2 (Ezh2), a histone lysine… read more here.
Keywords: ezh2 null; ezh2; lps tolerance; severe lps ... See more keywords