The chemotherapeutic drug carboplatin affects macrophage responses to LPS and LPS tolerance via epigenetic modifications
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DOI: 10.1038/s41598-021-00955-7
Abstract: Following re-exposure to lipopolysaccharide (LPS), macrophages exhibit an immunosuppressive state known as LPS tolerance, which is characterized by repressed proinflammatory cytokine production. LPS-induced tolerance in macrophages is mediated in part by epigenetic changes. Carboplatin, an… read more here.
Keywords: epigenetic modifications; tolerance; lps tolerant; lps tolerance ... See more keywords
SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling
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DOI: 10.1186/s13062-025-00669-0
Abstract: In sepsis, immunosuppression is commonly observed as lipopolysaccharide (LPS) tolerance in macrophages. Leukocyte immunoglobulin-like receptor B2 (LILRB2) is an inhibitory receptor on immune cells that may play a crucial role in the immunosuppressive phenotype of… read more here.
Keywords: lps tolerant; tolerant macrophages; immunosuppressive phenotype; phenotype lps ... See more keywords