The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.07.013
Abstract: HighlightsRepeated peripheral LPS administration increases expression of central A&bgr;.Administration of MRK‐016 post‐training rescues memory consolidation following LPS administration.MRK‐016‐treated animals showed BDNF mRNA expression comparable to control animals.Repeated injections of LPS and increased A&bgr; expression are… read more here.
Keywords: lps treated; mrk 016; expression; hippocampal bgr ... See more keywords
Protective effect of minocycline on LPS-induced mitochondrial dysfunction and decreased seizure threshold through nitric oxide pathway.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172446
Abstract: Lipopolysaccharide (LPS) increases inflammatory cytokines of the brain and deregulates the mitochondrial function, thus could increase the seizure susceptibility. Studies have shown that minocycline has neuroprotective and antioxidant properties. In this study, we aimed to… read more here.
Keywords: minocycline; seizure threshold; lps treated; effect ... See more keywords
Cytokine profile and nitric oxide levels in macrophages exposed to Leishmania infantum FML.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2019.05.004
Abstract: Fucose-mannose ligand (FML) is a soluble antigen purified from Leishmania donovani complex and used for diagnosis, prognosis, and vaccine development against visceral leishmaniasis (VL). We aimed to explore the effects of FML on the production… read more here.
Keywords: fml; lps treated; cytokine profile; nitric oxide ... See more keywords
Galuminox: Preclinical validation of a novel PET tracer for non-invasive imaging of oxidative stress in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101690
Abstract: Overproduction of reactive oxygen species (ROS) is a well-established indicator of ongoing tissue inflammation. However, there is a scarcity of molecular imaging probes capable of providing noninvasive sensitive detection of ROS for allowing longitudinal studies… read more here.
Keywords: novel; lps treated; tracer; galuminox ... See more keywords
MiR-702-3p inhibits the inflammatory injury in septic H9c2 cells by regulating NOD1.
Sign Up to like & getrecommendations! Published in 2021 at "Transplant immunology"
DOI: 10.1016/j.trim.2021.101493
Abstract: BACKGROUND Cardiac insufficiency is a common complication of sepsis and septic shock and is the most common cause of death in critically ill patients. Recent studies have found that microRNAs (miRNAs) play a potential role… read more here.
Keywords: treated h9c2; sepsis; h9c2 cells; lps treated ... See more keywords
The Decursin Analog, CYJ-27, Suppresses Inflammation Via the Downregulation of NF-κB and STAT-1.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal food"
DOI: 10.1089/jmf.2021.k.0027
Abstract: CYJ-27, a synthetic analog of decursin, prevents the generation of proinflammatory cytokines and oxidative stress. In this study, the effects of CYJ-27 on the regulation of inducible nitric oxide synthase (iNOS), heme oxygenase (HO)-1, and… read more here.
Keywords: analog; decursin analog; cyj; lps treated ... See more keywords
Necrostatin-1 promotes ectopic periodontal tissue like structure regeneration in LPS-treated PDLSCs
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DOI: 10.1371/journal.pone.0207760
Abstract: Necroptosis is a programmed necrosis, regulated by receptor interacting protein kinase 1(RIP1) and receptor interacting protein kinase 3(RIP3), and could be inhibited by necrostatin-1(Nec-1) specifically. This study aims to evaluate the effect of Nec-1 on… read more here.
Keywords: like structure; lps treated; periodontal tissue; treated pdlscs ... See more keywords
Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.2139/ssrn.4203227
Abstract: Pyroptosis, a newly discovered proinflammatory programmed cell death, is involved in the regulation of cognitive dysfunction, such as Alzheimer's disease. Exploring potential drug targets that prevent pyroptotic procedures might benefit the development of a cure… read more here.
Keywords: lps treated; pyroptosis pathway; hippocampal pyroptosis; treated mice ... See more keywords
Anti-Inflammatory Activity of Orally Administered Monostroma nitidum Rhamnan Sulfate against Lipopolysaccharide-Induced Damage to Mouse Organs and Vascular Endothelium
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DOI: 10.3390/md20020121
Abstract: We previously reported that rhamnan sulfate (RS) purified from Monostroma nitidum significantly suppressed lipopolysaccharide (LPS)-induced inflammation in cultured human vascular endothelial cells. Here, we analyzed the effect of orally administered RS on LPS-induced damage to… read more here.
Keywords: orally administered; lps treated; treated mice; organs vascular ... See more keywords