LRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating Hypoxia-inducible factor-1α.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1988368
Abstract: Cardiomyocyte apoptosis and autophagy play important roles in acute myocardial infarction (AMI), but the effect of leucine rich alpha-2-glycoprotein 1 (LRG1) on the apoptosis and autophagy of H9c2 has not yet been reported. It was… read more here.
Keywords: apoptosis; lrg1; apoptosis autophagy; hypoxia ... See more keywords
Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abe6805
Abstract: Description A temporal systems biology screen of premetastatic endothelial cells identified LRG1 as a therapeutic target for restricting metastases. A LaRGe effect on metastases A more complete understanding of the vascular niche as it evolves… read more here.
Keywords: lrg1; metastasis; vascular niche; growth ... See more keywords
Lrg1 Regulates β (1,3)-Glucan Masking in Candida albicans through the Cek1 MAP Kinase Pathway
Sign Up to like & getrecommendations! Published in 2019 at "mBio"
DOI: 10.1128/mbio.01767-19
Abstract: Candida albicans is an important source of systemic infections in humans. The ability to mask the immunogenic cell wall polymer β (1,3)-glucan from host immune surveillance contributes to fungal virulence. We previously reported that the… read more here.
Keywords: lrg1; map kinase; cek1; cell wall ... See more keywords
Abstract 3636: Liver endothelium secreted LRG1 promotes metastatic colorectal cancer growth through the HER3/RSK/EIF4B AXIS
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3636
Abstract: Background: 25% of patients diagnosed with colorectal cancer (CRC) have liver metastasis at presentation, and ~80% of all metastatic CRC are developed in the liver. We previously reported that liver endothelial cells (ECs), a key… read more here.
Keywords: lrg1; growth; her3; crc ... See more keywords
LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0175122
Abstract: Leucine-rich-alpha-2-glycoprotein 1 (LRG1) has been shown to be involved in various human malignancies. Whether it plays a role in colorectal cancer (CRC) development remains unclear. Here, we investigated whether and through what mechanism LRG1 functions… read more here.
Keywords: lrg1; colorectal cancer; proliferation; crc ... See more keywords
Leucine-Rich Alpha-2-Glycoprotein: A Novel Predictor of Diastolic Dysfunction
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030944
Abstract: Leucine-rich α2-glycoprotein (LRG1) mediates cardiac fibrocyte activation. It is upregulated in inflammatory conditions, atherosclerosis, and fibrosis. Diastolic dysfunction (DD) is due to myocardial fibrosis. This cross-sectional study examined the relationship between LRG1 and DD. Patients… read more here.
Keywords: glycoprotein; lrg1; leucine rich; syntax ... See more keywords
Serum and Urine Biomarker Leucine-Rich Alpha-2 Glycoprotein 1 Differentiates Pediatric Acute Complicated and Uncomplicated Appendicitis
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostics"
DOI: 10.3390/diagnostics11050860
Abstract: Purpose: This prospective, single-center cohort study analyzes the potential of inflammatory protein mediator leucine-rich alpha-2 glycoprotein 1 (LRG1) for the early and accurate diagnosis of acute appendicitis (AA), and differentiation of acute complicated (AcA) from… read more here.
Keywords: acute; leucine rich; lrg1; rich alpha ... See more keywords