LRH-1 high expression in the ovarian granulosa cells of PCOS patients
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-021-02774-2
Abstract: Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders with heterogeneity. There are also reports that liver receptor homolog 1 [LRH-1 or nuclear receptor subfamily 5 group A member 2] plays… read more here.
Keywords: expression ovarian; ovarian granulosa; lrh; expression ... See more keywords
Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00235
Abstract: Liver receptor homologue-1 (LRH-1) is a phospholipid-sensing nuclear receptor that has shown promise as a target for alleviating intestinal inflammation and metabolic dysregulation in the liver. LRH-1 contains a large ligand-binding pocket, but generating synthetic… read more here.
Keywords: lrh; modulation; nuclear receptor; pocket ... See more keywords
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00805
Abstract: Nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) is a lipid-regulated transcription factor and an important drug target for several liver diseases. Advances toward LRH-1 therapeutics have been driven recently by structural biology, with fewer contributions… read more here.
Keywords: full length; nuclear receptor; biology; lrh ... See more keywords
Clinical outcomes of laparoscopic versus open right hepatectomy for liver tumors
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000018667
Abstract: Abstract Background: Laparoscopic right hepatectomy (LRH) is one of the most challenging procedures. Right liver resections have been always performed in open procedure and open right hepatectomy (ORH) was initially considered as routine way. Moreover,… read more here.
Keywords: lrh; right hepatectomy; orh group; lrh group ... See more keywords