LRP1 deficiency in microglia blocks neuro‐inflammation in the spinal dorsal horn and neuropathic pain processing
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23599
Abstract: Following injury to the peripheral nervous system (PNS), microglia in the spinal dorsal horn (SDH) become activated and contribute to the development of local neuro‐inflammation, which may regulate neuropathic pain processing. The molecular mechanisms that… read more here.
Keywords: microglia; neuro inflammation; lrp1; neuropathic pain ... See more keywords
LRP1 Suppresses Bone Resorption in Mice by Inhibiting the RANKL‐Stimulated NF‐κB and p38 Pathways During Osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3469
Abstract: Single‐nucleotide polymorphisms in the LRP1 gene coding sequence are associated with low bone mass, and cell culture studies suggest that LRP1 plays a role in osteoblast proliferation and osteoblast‐mediated osteoclastogenesis. However, the in vivo function… read more here.
Keywords: p38 pathways; lrp1; bone; mice ... See more keywords
Clearance of matrix metalloproteinase‐9 is dependent on low‐density lipoprotein receptor‐related protein‐1 expression downregulated by microRNA‐205 in human abdominal aortic aneurysm
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2015.10.065
Abstract: Objective: Low‐density lipoprotein receptor‐related protein‐1 (LRP1) has been suggested to be a crucial regulator in the pathogenesis of abdominal aortic aneurysm (AAA) from previous genome association and animal studies. Our prior study using human aortic… read more here.
Keywords: lrp1 protein; lrp1; study; expression ... See more keywords
Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154191
Abstract: BACKGROUND Low-density lipoprotein receptor-related protein 1 (LRP1) plays a key role in fatty acid metabolism and glucose homeostasis. In the context of dyslipemia, LRP1 is upregulated in the heart. Our aim was to evaluate the… read more here.
Keywords: lipoprotein receptor; density lipoprotein; lrp1; low density ... See more keywords
The low density receptor-related protein 1 plays a significant role in ricin-mediated intoxication of lung cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65982-2
Abstract: Ricin, a highly lethal plant-derived toxin, is a potential biological threat agent due to its high availability, ease of production and the lack of approved medical countermeasures for post-exposure treatment. To date, no specific ricin… read more here.
Keywords: ricin; intoxication; receptor related; lrp1 ... See more keywords
Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92711-0
Abstract: Apolipoprotein A4 (APOA4) is one of the most abundant and versatile apolipoproteins facilitating lipid transport and metabolism. APOA4 is synthesized in the small intestine, packaged onto chylomicrons, secreted into intestinal lymph and transported via circulation… read more here.
Keywords: protein; apolipoprotein apoa4; lrp1; tissue ... See more keywords
Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1035-9
Abstract: The recent recovery of mutations in vesicular trafficking genes causing congenital heart disease (CHD) revealed an unexpected role for the endocytic pathway. We now show that mice with a C4232R missense mutation in Low density… read more here.
Keywords: heart; lrp1; neural crest; congenital heart ... See more keywords
Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.02.26.482111
Abstract: Oropouche orthobunyavirus (OROV; Peribunyaviridae) is a mosquito-transmitted virus that causes widespread cases of human febrile illness in South America, with occasional progression to neurologic effects. Host entry factors mediating cellular entry of OROV are undefined.… read more here.
Keywords: lrp1; infection; host factor; oropouche orthobunyavirus ... See more keywords
Autosomal recessive LRP1-related syndrome featuring cardiopulmonary dysfunction, bone dysmorphology, and corneal clouding
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a006169
Abstract: We provide the first study of two siblings with a novel autosomal recessive LRP1-related syndrome identified by rapid genome sequencing and overlapping multiple genetic models. The patients presented with respiratory distress, congenital heart defects, hypotonia,… read more here.
Keywords: recessive lrp1; lrp1; corneal clouding; lrp1 related ... See more keywords
NK cells promote intracellular infected trophoblasts survival via APOD-LRP1 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13621
Abstract: NK cells are known for their potent ability to kill stressed cells, whereas host cells infected with intracellular bacteria may also be benefit from the selective killing function of NK cells and survive. The mechanism… read more here.
Keywords: lrp1; cells promote; infected trophoblasts; promote intracellular ... See more keywords
Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8729398
Abstract: Cerebral ischemia/reperfusion (I/R) injury is a clinical event associated with high morbidity and mortality. Neuroinflammation plays a crucial role in the pathogenesis of I/R-induced brain injury and cognitive decline. Low-density lipoprotein receptor-related protein-1 (LRP1) can… read more here.
Keywords: lrp1; txnip; signaling pathway; nlrp3 signaling ... See more keywords