Chromosomal, epigenetic and microRNA-mediated inactivation of LRP1B, a modulator of the extracellular environment of thyroid cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.143
Abstract: The low-density lipoprotein receptor-related protein (LRP1B), encoding an endocytic LDL-family receptor, is among the 10 most significantly deleted genes across 3312 human cancer specimens. However, currently the apparently crucial role of this lipoprotein receptor in… read more here.
Keywords: epigenetic microrna; lrp1b; chromosomal epigenetic; cancer cells ... See more keywords
Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02405-9
Abstract: Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics… read more here.
Keywords: lrp1b; patients copd; sequencing data; analysis ... See more keywords
Immune checkpoint inhibitor response in tumors with LRP1B variants.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14291
Abstract: e14291 Background: Low-density lipoprotein receptor-related protein 1B (LRP1B) is a putative tumor suppressor gene spanning > 500 kb on chromosome 2. A melanoma study previously reported enrichment of LRP1B mutations in responders (34%) to immune… read more here.
Keywords: checkpoint inhibitor; response; immune checkpoint; lrp1b ... See more keywords
Integrative analysis of the proteome and transcriptome in gastric cancer identified LRP1B as a potential biomarker.
Sign Up to like & getrecommendations! Published in 2023 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2022-0288
Abstract: Background: The aim of this study was to discover unique membrane proteins associated with gastric cancer (GC) in proteomics analysis. Methods: Using a data-independent acquisition strategy, we compared the relative expression levels of membrane proteins… read more here.
Keywords: membrane proteins; gastric cancer; integrative analysis; lrp1b ... See more keywords