Lrp5 Mutant and Crispant Zebrafish Faithfully Model Human Osteoporosis, Establishing the Zebrafish as a Platform for CRISPR‐Based Functional Screening of Osteoporosis Candidate Genes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4327
Abstract: Genomewide association studies (GWAS) have improved our understanding of the genetic architecture of common complex diseases such as osteoporosis. Nevertheless, to attribute functional skeletal contributions of candidate genes to osteoporosis‐related traits, there is a need… read more here.
Keywords: crispr based; osteoporosis candidate; candidate genes; osteoporosis ... See more keywords
A novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-β/Smad signaling
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DOI: 10.1038/s41392-020-0142-x
Abstract: Previous studies by us and others demonstrated that activation of Wnt/β-catenin signaling plays a pathogenic role in chronic kidney diseases (CKD). Wnt co-receptor LRP5 variants are reported to associate with autosomal dominant polycystic kidney disease;… read more here.
Keywords: tgf smad; smad signaling; role; tubulointerstitial fibrosis ... See more keywords
Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.985304
Abstract: Low-density Lipoprotein Receptor-related Protein 5 (LRP5) functions as a co-receptor for Wnt ligands, controlling expression of genes involved in osteogenesis. In humans, loss-of-function mutations in LRP5 cause Osteoporosis-Pseudoglioma syndrome, a low bone mass disorder, while… read more here.
Keywords: function; zebrafish mutants; bone; role lrp5 ... See more keywords
Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1/moesin-mediated inhibition of TGFβ/FN1/CD44 signaling
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DOI: 10.7150/thno.66148
Abstract: Background: Bone is a frequent site of metastases from breast cancer, but existing therapeutic options are not satisfactory. Although osteoblasts have active roles in cancer progression by assisting the vicious bone-destructive cycle, we employed a… read more here.
Keywords: cancer; tumor; breast cancer; hsp90ab1 ... See more keywords