Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism.
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DOI: 10.1016/j.bone.2018.10.007
Abstract: High-bone-mass (HBM)-causing missense mutations in the low density lipoprotein receptor-related protein-5 (Lrp5) are associated with increased osteoanabolic action and protection from disuse- and ovariectomy-induced osteopenia. These mutations (e.g., A214V and G171V) confer resistance to endogenous… read more here.
Keywords: hbm; lrp5 hbm; expressing cells; hbm causing ... See more keywords