Combination therapy in the Col2a1G610C mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFβ signaling on trabecular bone but not on cortical bone.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115084
Abstract: Enhancing LRP5 signaling and inhibiting TGFβ signaling have each been reported to increase bone mass and improve bone strength in wild-type mice. Monotherapy targeting LRP5 signaling, or TGFβ signaling, also improved bone properties in mouse… read more here.
Keywords: bone; lrp5 signaling; tgf signaling; trabecular bone ... See more keywords
Knockdown of LncRNA SBF2-AS1 Inhibited Gastric Cancer Tumorigenesis via the Wnt/LRP5 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Acta medica Okayama"
DOI: 10.18926/amo/64112
Abstract: This investigation aimed to uncover the impact of a long noncoding RNA, SET-binding factor 2 antisense RNA1 (SBF2-AS1) on the malignant progression of gastric cancer (GC) and to further explore its underlying mechanism. SBF2-AS1 expression… read more here.
Keywords: signaling pathway; lrp5 signaling; sbf2; wnt lrp5 ... See more keywords