Computationally Design of Inhibitory Peptides Against Wnt Signaling Pathway: In Silico Insight on Complex of DKK1 and LRP6
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-017-9589-1
Abstract: Wnt signaling pathway plays a major role in the regulation of cell proliferation, migration, tissue homeostasis, tumor progression and cancer. This pathway can be antagonized by different proteins such as DKK proteins, which disrupt the… read more here.
Keywords: wnt signaling; dkk1; design inhibitory; lrp6 ... See more keywords
A Role for Low-Density Lipoprotein Receptor-Related Protein 6 in Blood Vessel Regression in Wound Healing.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in wound care"
DOI: 10.1089/wound.2019.1019
Abstract: Objective: The healing of skin wounds is typified by a pattern of robust angiogenesis followed by vascular regression. Pigment epithelium-derived factor (PEDF), a recognized endogenous antiangiogenic protein, regulates vascular regression in resolving wounds through an… read more here.
Keywords: wound healing; regression; lrp6; vessel regression ... See more keywords
Activation of LRP6 with HLY78 Attenuates Oxidative Stress and Neuronal Apoptosis via GSK3β/Sirt1/PGC-1α Pathway after ICH
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7542468
Abstract: Background Oxidative stress and neuronal apoptosis have important roles in the pathogenesis after intracerebral hemorrhage (ICH). Previous studies have reported that low-density lipoprotein receptor-related protein 6 (LRP6) exerts neuroprotection in several neurological diseases. Herein, we… read more here.
Keywords: neuronal apoptosis; lrp6; oxidative stress; stress neuronal ... See more keywords
LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25187
Abstract: Triple-negative breast cancers (TNBCs) account for a large proportion of breast cancer deaths, due to the high rate of recurrence from residual, resistant tumor cells. New treatments are needed, to bypass chemoresistance and improve survival.… read more here.
Keywords: negative breast; breast; lrp6; target ... See more keywords
LRP6 Polymorphisms Is Associated With Sudden Cardiac Death in Patients With Chronic Heart Failure in the Chinese Han Population
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.815595
Abstract: Low-density lipoprotein receptor-related protein 6 (LRP6) plays a critical role in cardiovascular homeostasis. The deficiency of LRP6 is associated with a high risk of arrhythmias. However, the association between genetic variations of LRP6 and sudden… read more here.
Keywords: chronic heart; lrp6; scd; cardiac death ... See more keywords
Low-density lipoprotein receptor-related protein 6 regulates cardiomyocyte-derived paracrine signaling to ameliorate cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.48787
Abstract: Rationale: Maladaptive cardiac remodeling is a critical step in the progression of heart failure. Low-density lipoprotein receptor-related protein 6 (LRP6), a co-receptor of Wnt, has been implicated in cardiac protection. We aimed to study the… read more here.
Keywords: fibrosis; cardiac fibrosis; lrp6; wnt5a wnt11 ... See more keywords