LRRC8A is dispensable for a variety of microglial functions and response to acute stroke
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DOI: 10.1002/glia.24156
Abstract: Microglia, resident brain immune cells, are critical in orchestrating responses to central nervous system (CNS) injury. Many microglial functions, such as phagocytosis, motility and chemotaxis, are suggested to rely on chloride channels, including the volume‐regulated… read more here.
Keywords: cell; lrrc8a; lrrc8a dispensable; vrac ... See more keywords
LRRC8A potentiates temozolomide sensitivity in glioma cells via activating mitochondria-dependent apoptotic pathway
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DOI: 10.1007/s13577-018-0221-2
Abstract: Chloride (Cl−), a primary anion in the extracellular fluid, plays an important role in a variety of physiological and pathological processes, such as cell apoptosis and proliferation. However, the information about Cl− in cancer cell… read more here.
Keywords: u87 cells; apoptosis; lrrc8a; mitochondria dependent ... See more keywords
LRRC8A Anion Channel Knockout Stimulates the Nrf2 Antioxidant Response
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DOI: 10.1152/physiol.2023.38.s1.5732507
Abstract: Leucine Rich Repeat Containing 8A (LRRC8A) is an essential component of volume‐regulated anion channels (VRACs), which regulate cell volume. These anion channels are activated by pro-inflammatory mediators such as angiotensin II and tumor necrosis factor-α… read more here.
Keywords: antioxidant response; lrrc8a; physiology; anion ... See more keywords
LRRC8A Anion Channel Associates with Myosin Phosphatase Rho Interacting Protein (MPRIP) to Regulate Vascular Function
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DOI: 10.1152/physiol.2023.38.s1.5732946
Abstract: Volume-regulated anion channels (VRACs) are activated by tumor necrosis factor alpha (TNFα) and angiotensin II. VRACs are composed of Leucine Rich Repeat Containing 8 (LRRC8) family proteins (LRRC8A, B, C, D and E) and LRRC8A… read more here.
Keywords: mprip; lrrc8a; physiology; phosphatase rho ... See more keywords
LRRC8A critically regulates myofibroblast phenotypes and fibrotic remodeling following myocardial infarction
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DOI: 10.7150/thno.75200
Abstract: Rationale: The transformation of fibroblasts into activated myofibroblasts is a critical step that results in cardiac fibrosis upon myocardial infarction (MI). Leucine-rich repeat-containing protein-8A (LRRC8A) is a multi-functional protein involved in cell survival, growth, and… read more here.
Keywords: fibrotic remodeling; cardiac fibrosis; lrrc8a; myocardial infarction ... See more keywords