Leucine rich repeat kinase knockout (LRRK KO) mouse model: Linking pathological hallmarks of inherited and sporadic Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27267
Abstract: Autosomal dominant mutations in Leucine Rich Repeat Kinase 2 (LRRK2) underlie the most common cause of familial Parkinson’s disease (PD) and have also been associated with sporadic cases. However, LRRK2 mutation knockin and LRRK2 knockout… read more here.
Keywords: dko mice; lrrk dko; lrrk; lrrk2 ... See more keywords
Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology reports"
DOI: 10.3892/or.2017.5974
Abstract: Although gemcitabine (GEM) is frequently used in the treatment of pancreatic cancer, the effects are limited. To increase the inhibitory effect of GEM, the identification of a molecular target is needed. Recent studies have revealed… read more here.
Keywords: gem; treatment; pancreatic cancer; lrrk ... See more keywords