Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
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DOI: 10.7554/elife.67900
Abstract: Activating LRRK2 mutations cause Parkinson’s disease, and pathogenic LRRK2 kinase interferes with ciliogenesis. Previously, we showed that cholinergic interneurons of the dorsal striatum lose their cilia in R1441C LRRK2 mutant mice (Dhekne et al., 2018).… read more here.
Keywords: hedgehog signaling; cilia loss; lrrk2; pathogenic lrrk2 ... See more keywords