The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abk3411
Abstract: Gain-of-function mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are common in familial forms of Parkinson’s disease (PD), which is characterized by progressive neurodegeneration that impairs motor and cognitive function. We previously demonstrated that… read more here.
Keywords: aicd; parkinson disease; lrrk2 expression; feed forward ... See more keywords
Mild Chronic Colitis Exacerbates Intracerebral Inflammation in Mice with Parkinson’s Disease Through LRRK2-Mediated Regulation of NF-κB Activation and Inhibition of Nrf2
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s526777
Abstract: Background and Objective Inflammatory bowel disease (IBD) is a known risk factor for Parkinson’s disease (PD). Leucine-rich repeat kinase 2 (LRRK2), a protein associated with both disease, regulates inflammation in the colon and brain. However,… read more here.
Keywords: disease; brain; lrrk2; inflammation ... See more keywords