The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson’s disease
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DOI: 10.1126/scisignal.abk3411
Abstract: Gain-of-function mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are common in familial forms of Parkinson’s disease (PD), which is characterized by progressive neurodegeneration that impairs motor and cognitive function. We previously demonstrated that… read more here.
Keywords: aicd; parkinson disease; lrrk2 expression; feed forward ... See more keywords