Association of a Prophylactic Surgical Approach to Stage IV Small Intestinal Neuroendocrine Tumors With Survival
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.3326
Abstract: Importance Primary tumor resection and mesenteric lymph node dissection in asymptomatic patients with stage IV small intestinal neuroendocrine tumors (SI-NETs) are controversial. Objective To determine the association of locoregional surgery (LRS) performed at diagnosis with… read more here.
Keywords: surgery; small intestinal; treatment; stage small ... See more keywords
Long‐read sequencing for molecular diagnostics in constitutional genetic disorders
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24465
Abstract: Long‐read sequencing (LRS) has been around for more than a decade, but widespread adoption of the technology has been slow due to the perceived high error rates and high sequencing cost. This is changing due… read more here.
Keywords: diagnostics constitutional; sequencing molecular; lrs; read sequencing ... See more keywords
Weak and strong orders of linear recurring sequences
Sign Up to like & getrecommendations! Published in 2018 at "Computational and Applied Mathematics"
DOI: 10.1007/s40314-017-0532-z
Abstract: The concept of the strong order of linear recurring sequence (LRS) is introduced in this paper. Necessary and sufficient conditions for the existence of the strong LRS order are derived. The strong LRS order is… read more here.
Keywords: order; linear recurring; lrs order; lrs ... See more keywords
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00785-0
Abstract: Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, the pathophysiological significance of its activity is not well understood. Here, we demonstrate that the… read more here.
Keywords: mtorc1 pathway; mtorc1; leucyl trna; trna synthetase ... See more keywords
Detection of large rearrangements in a hereditary pan-cancer panel using next-generation sequencing
Sign Up to like & getrecommendations! Published in 2019 at "BMC Medical Genomics"
DOI: 10.1186/s12920-019-0587-3
Abstract: BackgroundHealthcare providers increasingly use information about pathogenic variants in cancer predisposition genes, including sequence variants and large rearrangements (LRs), in medical management decisions. While sequence variant detection is typically robust, LRs can be difficult to… read more here.
Keywords: detection; lrs; cancer; next generation ... See more keywords
Two-step production of anti-inflammatory soluble factor by Lactobacillus reuteri CRL 1098
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0200426
Abstract: We have demonstrated previously that a soluble factor (LrS) produced by Lactobacillus (L.) reuteri CRL 1098 modulates the inflammatory response triggered by lipopolysaccharide. In this study, the production of LrS by L. reuteri CRL 1098… read more here.
Keywords: crl 1098; production; lrs; reuteri crl ... See more keywords
Lipid metabolism-related gene signature predicts prognosis and depicts tumor microenvironment immune landscape in gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1021678
Abstract: Background Glioma is the most common primary brain tumor in adults and accounts for more than 70% of brain malignancies. Lipids are crucial components of biological membranes and other structures in cells. Accumulating evidence has… read more here.
Keywords: lipid metabolism; risk; glioma; score ... See more keywords