Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23805
Abstract: Fluoride induces endoplasmic reticulum (ER) stress in ameloblasts, which is responsible for enamel mineralization disorder. Fluoride induces autophagy in ameloblasts, but the molecular mechanisms through which ameloblasts respond to fluoride-induced cellular stress and autophagy remain… read more here.
Keywords: chaperone grp78; stress; ls8 cells; fluoride induced ... See more keywords
Calcium promotes differentiation in ameloblast-like LS8 cells by downregulation of phosphatidylinositol 3 kinase /protein kinase B pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.104579
Abstract: OBJECTIVES To investigate the effect and mechanism of calcium on LS8 cell differentiation, especially on phosphatidylinositol 3 kinase (PI3K) /protein kinase B(AKT) pathway. MATERIALS AND METHODS Ameloblast-like LS8 cell line was used and additional 0-3.5 mmol/L… read more here.
Keywords: ls8; ls8 cells; phosphatidylinositol kinase; differentiation ... See more keywords
Transcriptomic analysis of MicroRNA expression in enamel-producing cells.
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DOI: 10.1016/j.gene.2018.11.089
Abstract: There is little evidence for the involvement of microRNAs (miRNAs) in the regulation of circadian rhythms during enamel development. Few studies have used ameloblast-like cell line LS8 to study the circadian rhythm of gene activities… read more here.
Keywords: analysis microrna; analysis; ls8 cells; transcriptomic analysis ... See more keywords