Signaling Pathways in Leukemic Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7342-8_1
Abstract: Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) utilize many of the same signaling pathways for their maintenance and survival. In this review, we will focus on several signaling pathways whose roles have been… read more here.
Keywords: signaling pathways; pathways leukemic; leukemic stem; stem cells ... See more keywords
A comprehensive system of definitions of land surface (topographic) curvatures, with implications for their application in geoscience modelling and prediction
Sign Up to like & getrecommendations! Published in 2020 at "Earth-Science Reviews"
DOI: 10.1016/j.earscirev.2020.103414
Abstract: Abstract Current use of land surface curvatures (LSCs) is in a confused state as a large gap has opened up between applications and theoretical work. LSCs exercise important control on changes of gravity potential energy… read more here.
Keywords: interpretation; surface; land surface; comprehensive system ... See more keywords
Low reabsorption and stability enhanced luminescent solar concentrators based on silica encapsulated quantum rods
Sign Up to like & getrecommendations! Published in 2020 at "Solar Energy Materials and Solar Cells"
DOI: 10.1016/j.solmat.2019.110321
Abstract: Abstract Luminescent nanocrystals (NCs) based luminescent solar concentrators (LSCs) are promising as a new concept for solar energy collection. The reabsorption behavior and the stability are two critical issues for the luminophores in LSCs. Here… read more here.
Keywords: luminescent solar; reabsorption; solar concentrators; silica encapsulated ... See more keywords
Super-enhancer landscape reveals leukemia stem cell reliance on X-box binding protein 1 as a therapeutic vulnerability
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abh3462
Abstract: Description Leukemia stem cells are dependent on the super-enhancer–associated oncogene XBP1, suggesting a potential targeting strategy in relapsed CML. Exploring the epigenetic landscape of leukemia stem cells Leukemia stem cells (LSCs) are often persistent in… read more here.
Keywords: cml; super enhancer; stem; lscs ... See more keywords
A Microenvironment Screen Identifies Compounds Targeting pre-LSCs.
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DOI: 10.1158/2159-8290.cd-rw2016-212
Abstract: 2-ME2 selectively targets pre-LSCs by inhibiting MYC translation and SCL activity. read more here.
Keywords: screen identifies; identifies compounds; microenvironment screen; compounds targeting ... See more keywords
CD93-Signaling Regulates Self-Renewal and Proliferation of Chronic Myeloid Leukemia Stem Cells in Mice and Humans and Might be a Promising Target for Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-127864
Abstract: Background: The introduction of BCR/ABL-specific tyrosine kinase inhibitors (TKIs) more than two decades ago revolutionized chronic myelogenous leukemia (CML) therapy. The majority of CML patients treated with TKIs obtain durable cytogenetic and molecular responses. However,… read more here.
Keywords: cml; treatment; cd93; self renewal ... See more keywords