Hot-spot guided design of macrocyclic inhibitors of the LSD1-CoREST1 interaction
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DOI: 10.1016/j.tet.2019.130685
Abstract: Abstract New modalities such as cyclic peptides are attractive structures to inhibit challenging targets. The interaction between LSD1 and CoREST1 is required for histone demethylation and represents an attractive therapeutic target. The large interaction surface… read more here.
Keywords: guided design; lsd1 corest1; interaction; hot spot ... See more keywords