LSD1 inhibition disrupts super-enhancer driven oncogenic transcriptional programs in castration-resistant prostate cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-2433
Abstract: The lysine demethylase LSD1 (also called KDM1A) plays important roles in promoting multiple malignancies including both hematologic cancers and solid tumors. LSD1 targets histone and non-histone proteins and can function as a transcriptional corepressor and… read more here.
Keywords: prostate cancer; castration resistant; super enhancer; cancer ... See more keywords
Abstract 2034: LSD1 inhibition alone and in combination with chemotherapy in Ewing sarcoma cell lines
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DOI: 10.1158/1538-7445.am2017-2034
Abstract: Background: Ewing Sarcoma (ES) is the second most common primary bone cancer affecting children and young adults. Despite advances in treatment that have led to survival rates of approximately 73% for localized disease, outcomes for… read more here.
Keywords: combination; cell lines; ewing sarcoma; lsd1 inhibition ... See more keywords
Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition.
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DOI: 10.1158/2159-8290.cd-19-1469
Abstract: The cell of origin of oncogenic transformation is a determinant of therapeutic sensitivity, but the mechanisms governing cell-of-origin-driven differences in therapeutic response have not been delineated. Leukemias initiating in hematopoietic stem cells (HSC) are less… read more here.
Keywords: sensitivity; apoptotic priming; cell origin; lsd1 inhibition ... See more keywords
LSD1 inhibition modulates transcription factor networks in myeloid malignancies
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DOI: 10.3389/fonc.2023.1149754
Abstract: Acute Myeloid Leukemia (AML) is a type of cancer of the blood system that is characterized by an accumulation of immature hematopoietic cells in the bone marrow and blood. Its pathogenesis is characterized by an… read more here.
Keywords: transcription; transcription factor; transcription factors; factor networks ... See more keywords