Non-invasive dynamic monitoring initiation and growth of pancreatic tumor in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2018.11.009
Abstract: The LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mouse is one of the most widely used transgenic models to evaluate tumor characteristics and to develop novel therapies for pancreatic ductal adenocarcinoma (PDAC). There is no report of the effective systemic… read more here.
Keywords: lsl krasg12d; growth; kpc; krasg12d lsl ... See more keywords
HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer
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DOI: 10.1038/bjc.2017.216
Abstract: Background:Pancreatic cancer is currently the third leading cause of cancer deaths in the United States and it is predicted to become the second by the year 2030. High-mobility group A1 protein (HMGA1) is an oncogenic… read more here.
Keywords: ptf1a cre; cre lsl; pancreatic cancer; cancer ... See more keywords
Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury
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DOI: 10.1038/s41388-017-0100-4
Abstract: Pancreatic cancer (PDAC) is one of the most dismal of human malignancies. Inhibiting or delaying the progression of precursor lesions of PDAC, pancreatic intraepthial neoplasia (PanINs), to invasive cancer, would be a major step. In… read more here.
Keywords: snail1; pancreatic injury; acinar ductal; lsl ... See more keywords
Development of thymic tumor in [LSL:KrasG12D; Pdx1-CRE] mice, an adverse effect associated with accelerated pancreatic carcinogenesis
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DOI: 10.1038/s41598-021-94566-x
Abstract: Pancreatic Ductal AdenoCarcinoma (PDAC) represents about 90% of pancreatic cancers. It is one of the most aggressive cancer, with a 5-year survival rate below 10% due to late diagnosis and poor therapeutic efficiency. This bad… read more here.
Keywords: krasg12d pdx1; krasg12d; adverse effect; lsl krasg12d ... See more keywords