Respiratory Safety of Lemborexant in Healthy Subjects: A Single-Dose, Randomized, Double-Blind, Placebo-Controlled, Crossover Study
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-021-01018-5
Abstract: Lemborexant is a dual orexin receptor antagonist recently approved in the USA, Japan, and Canada for the treatment of adults with insomnia. Because some pharmacotherapy for insomnia causes respiratory depression, this study assessed the effects… read more here.
Keywords: medicine; study; placebo; lsm difference ... See more keywords
Respiratory safety of lemborexant in healthy adult and elderly subjects with mild obstructive sleep apnea: A randomized, double‐blind, placebo‐controlled, crossover study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Sleep Research"
DOI: 10.1111/jsr.13021
Abstract: Lemborexant is a dual orexin receptor antagonist indicated for the treatment of adult and elderly individuals with insomnia. Some current pharmacologic treatments for insomnia cause respiratory depression, a serious safety concern, particularly for individuals with… read more here.
Keywords: respiratory safety; lsm difference; treatment; placebo ... See more keywords