Triiodothyronine alongside levothyroxine in the management of hypothyroidism?
Sign Up to like & getrecommendations! Published in 2021 at "Current medical research and opinion"
DOI: 10.1080/03007995.2021.1984219
Abstract: The current guideline-based management of hypothyroidism recommends monotherapy with levothyroxine (LT4), titrated to maintain the level of thyrotropin within a euthyroid reference range. This has been successful for most people with hypothyroidism, but a substantial… read more here.
Keywords: hypothyroidism; management hypothyroidism; combination therapy; lt4 ... See more keywords
Getting the levothyroxine (LT4) dose right for adults with hypothyroidism: opportunities and challenges in the use of modern LT4 preparations
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2022.2071059
Abstract: Abstract Lifelong treatment with levothyroxine (LT4) is the mainstay of management for individuals with hypothyroidism. Many hypothyroid patients start LT4 treatment at a low dose (e.g. 25–50 µg), especially the elderly, those with residual thyroid function,… read more here.
Keywords: getting levothyroxine; dose; lt4 preparations; treatment ... See more keywords
Evaluation of the interaction of levothyroxine with bovine serum albumin using spectroscopic and molecular docking studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1822919
Abstract: Abstract Bovine serum albumin (BSA) acts as a carrier for many endogenous and exogenous compounds, such as thyroid hormones or corresponding drugs. Binding of the hydrophilic levothyroxine drug (LT4) to BSA is of significant pharmacological… read more here.
Keywords: lt4 bsa; lt4; bovine serum; serum albumin ... See more keywords
Efficacy of subcutaneous Levothyroxine in a case of refractory hypothyroidism: A case report
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029690
Abstract: Rationale: Daily oral synthetic levothyroxine (LT4) is the main treatment for hypothyroidism, which, in most cases, allows the regression of symptoms and the normalization of the thyroid function. However, rarely, despite a high dose of… read more here.
Keywords: refractory hypothyroidism; case; treatment; hypothyroidism ... See more keywords
Treatment of congenital hypothyroidism - impact of secular changes in levothyroxine initial dose on early growth.
Sign Up to like & getrecommendations! Published in 2022 at "Hormone research in paediatrics"
DOI: 10.1159/000528567
Abstract: INTRODUCTION Newborn screening of congenital hypothyroidism (CH) has enabled early treatment with levothyroxine (LT4), ensuring normal growth and development. The initial LT4 dose recommendation has increased over decades. We evaluated whether the increased LT4 dosing… read more here.
Keywords: growth; two years; lt4 dose; treatment ... See more keywords
Use of thyroid hormones in hypothyroid and euthyroid patients: A THESIS questionnaire survey of Hungarian physicians
Sign Up to like & getrecommendations! Published in 2022 at "Orvosi hetilap"
DOI: 10.1556/650.2022.32412
Abstract: Összefoglaló. Bevezetés: A pajzsmirigy-alulműködés gyakori betegség. Kezelésében a levotiroxin (LT4)-pótlás a szokásos eljárás, mely tabletta vagy gélkapszula formájában áll rendelkezésre Magyarországon. A nemzetközi trendeknek megfelelően az esetek korai felismerése miatt már a kevésbé kifejezett hormonális… read more here.
Keywords: thesis; survey; magyar endokrinol; treatment ... See more keywords
Conformational Changes in the BSA-LT4 Complex Induced by the Presence of Vitamins: Spectroscopic Approach and Molecular Docking
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DOI: 10.3390/ijms23084215
Abstract: Levothyroxine (LT4) is known for its use in various conditions including hypothyroidism. LT4 interaction with serum albumin may be influenced by the presence of vitamins. For this reason, we investigated the effect of vitamin C,… read more here.
Keywords: spectroscopy; bsa lt4; vitamin b12; lt4 ... See more keywords
Liquid levothyroxine improves thyroid control in patients with different hypothyroidism aetiology and variable adherence - case series and review.
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DOI: 10.5603/ep.a2022.0078
Abstract: It is estimated that hypothyroidism treatment may be either suboptimal or excessive in about 32-45% patients treated with L-thyroxine (LT4). There are multiple possible causes of poor control of hypothyroidism, including narrow LT4 therapeutic index,… read more here.
Keywords: adherence; control; liquid lt4; lt4 absorption ... See more keywords