Frequency–dependency of the involvement of dopamine D1/D5 and beta‐adrenergic receptors in hippocampal LTD triggered by locus coeruleus stimulation
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23419
Abstract: Patterned stimulation of the locus coeruleus (LC, 100 Hz), in conjunction with test‐pulse stimulation of hippocampal afferents, results in input‐specific long‐term depression (LTD) of synaptic plasticity in the hippocampus. Effects are long‐lasting and have been described… read more here.
Keywords: frequency; ltd; hippocampal ltd; ltd triggered ... See more keywords
αCaMKII in the lateral amygdala mediates PTSD-Like behaviors and NMDAR-Dependent LTD
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2021.100359
Abstract: Post-traumatic stress disorder (PTSD) is a psychiatric disorder that afflicts many individuals. However, its molecular and cellular mechanisms remain largely unexplored. Here, we found PTSD susceptible mice exhibited significant up-regulation of alpha-Ca2+/calmodulin-dependent kinase II (αCaMKII)… read more here.
Keywords: lateral amygdala; ltd; like behaviors; camkii ... See more keywords
Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1321061
Abstract: Abstract Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption. This study was undertaken to develop and statistically optimize transfersomal gel… read more here.
Keywords: bioavailability; transferosomal gel; ltd; optimization ... See more keywords
Satisfaction of Pakistan’s Islamic banking system during the COVID-19 pandemic Logistic model-based identification of the determinants to improve customer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Islamic Marketing"
DOI: 10.1108/jima-06-2020-0189
Abstract: Purpose: This study aims to explore the potential determinants of customers’ satisfaction with the Islamic banking system and highlights the fact that both internal and external factors play key roles in customer satisfaction (CS) during… read more here.
Keywords: bank; customer; ltd; satisfaction ... See more keywords
The Story of the LTD Development
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Plasma Science"
DOI: 10.1109/tps.2019.2954210
Abstract: In this article, the story of linear transformer driver (LTD) development is presented, which began in the 1980s when the inductive energy storage (IES) systems with plasma opening switches (POSs) were the focus of pulsed… read more here.
Keywords: ltd; development; story ltd; technology ... See more keywords
Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid‐β peptide exposure
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15575
Abstract: Amyloid‐β peptides (Aβ) accumulate in the brain since early Alzheimer's disease (AD) and dysregulate hippocampal synaptic plasticity, the neurophysiological basis of memory. Although the relationship between long‐term potentiation (LTP) and memory processes is well established,… read more here.
Keywords: early alzheimer; alzheimer disease; ltd; hippocampal synaptic ... See more keywords
OP0035 Upadacitinib as monotherapy: a phase 3 randomised controlled double-blind study in patients with active rheumatoid arthritis and inadequate response to methotrexate
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4237
Abstract: Background Upadacitinib (UPA), an oral JAK inhibitor, showed efficacy in rheumatoid arthritis (RA) patients (pts) with an inadequate response to csDMARDs or bDMARDs on continuing stable csDMARD(s).1 2 Objectives Safety and efficacy of switching to… read more here.
Keywords: abbvie; inadequate response; ltd; mtx ... See more keywords
THU0173 FILGOTINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS AND PRIOR INADEQUATE RESPONSE OR INTOLERANCE TO BIOLOGICAL DMARDS (BDMARD-IR) BY RACE & GEOGRAPHIC REGION
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.2323
Abstract: Background Filgotinib (FIL), an oral, selective Janus kinase 1 (JAK1) inhibitor, significantly improved the signs and symptoms of rheumatoid arthritis (RA) in the phase 3 FINCH2 study in bDMARD-IR patients with active RA.1 Objectives To… read more here.
Keywords: fil; region; ltd; fil 200 ... See more keywords
AB1026 CLINICAL PRACTICE GUIDANCE FOR THE TRANSITIONAL CARE OF YOUNG PEOPLE WITH JUVENILE-ONSET RHEUMATIC DISORDERS IN JAPAN
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3877
Abstract: Background The transition from pediatric to adult healthcare systems has recently received worldwide attention, and it is “the purposeful, planned movement of adolescents and young adults with chronic physical and medical conditions from child-centered to… read more here.
Keywords: ltd; guidance; rheumatology; speakers bureau ... See more keywords
AB0494 CHARACTERISTICS OF THE PATIENTS WITH POLYARTERITIS NODOSA IN JAPAN
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1289
Abstract: Since the number of polyarteritis nodosa (PAN) patients is small not only in Japan but also in the world, the characteristics of PAN have not been fully clarified and appropriate treatment has not been established.This… read more here.
Keywords: ltd; japan; none declared; pharma ... See more keywords
THU0217 UPADACITINIB MONOTHERAPY IN METHOTREXATE-NAÏVE PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS AT 72 WEEKS FROM SELECT-EARLY
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1857
Abstract: Upadacitinib (UPA), an oral JAK inhibitor, demonstrated significant improvements in signs, symptoms, and structural inhibition as monotherapy vs methotrexate (MTX) in a randomized, controlled trial (RCT) of MTX-naive RA patients (pts) through 48 weeks (wks).1To… read more here.
Keywords: mtx; ltd; inc; monotherapy ... See more keywords