A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14772
Abstract: A mutation in the GBA1 gene is the most common genetic risk factor for developing Parkinson's disease. GBA1 encodes the lysosomal enzyme glucosylceramidase beta (glucocerebrosidase, GCase) and mutations decrease enzyme activity. LTI‐291 is an allosteric… read more here.
Keywords: randomized single; glucocerebrosidase; single multiple; lti 291 ... See more keywords