X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4+ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.03424-19
Abstract: HIV-1 latency featuring silence of transcription from HIV-1 proviral DNA represents a major obstacle for HIV-1 eradication. Reversible repression of HIV-1 5′-LTR-mediated transcription represents the main mechanism for HIV-1 to maintain latency. The 5′-LTR-driven HIV… read more here.
Keywords: ltr; hiv; transcription; proviral dna ... See more keywords
iPiDA-LTR: Identifying piwi-interacting RNA-disease associations based on Learning to Rank
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DOI: 10.1371/journal.pcbi.1010404
Abstract: Piwi-interacting RNAs (piRNAs) are regarded as drug targets and biomarkers for the diagnosis and therapy of diseases. However, biological experiments cost substantial time and resources, and the existing computational methods only focus on identifying missing… read more here.
Keywords: piwi interacting; ipida ltr; based learning; disease associations ... See more keywords
Distributionally robust learning-to-rank under the Wasserstein metric
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DOI: 10.1371/journal.pone.0283574
Abstract: Despite their satisfactory performance, most existing listwise Learning-To-Rank (LTR) models do not consider the crucial issue of robustness. A data set can be contaminated in various ways, including human error in labeling or annotation, distributional… read more here.
Keywords: distributionally robust; drmrr; learning rank; ltr ... See more keywords
Genomic and evolutionary diversity of LTR retrotransposons in date palm (Phoenix dactylifera)
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DOI: 10.30848/pjb2019-5(51)
Abstract: Of the transposable elements (TEs), the retrotransposons are the most copious elements identified from many sequenced genomes. They have played a major role in genome evolution, rearrangement and expansions based on their copy and paste… read more here.
Keywords: ltr; ltr retrotransposons; genomic evolutionary; phoenix dactylifera ... See more keywords
Genetic Diversity of the LTR Region of Polish SRLVs and Its Impact on the Transcriptional Activity of Viral Promoters
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DOI: 10.3390/v15020302
Abstract: A long terminal repeat (LTR) plays an indispensable role in small ruminant lentivirus (SRLV) gene expression. In this study, we present the LTR sequence of Polish SRLVs representing different subtypes, and analyzed their impact on… read more here.
Keywords: promoter; genetic diversity; polish srlvs; ltr ... See more keywords