Abstract B015: Wildtype RAS activity and PI3K signaling as new vulnerabilities in cells with acquired resistance to sotorasib
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DOI: 10.1158/1557-3125.ras23-b015
Abstract: Purpose: Sotorasib (AMG510) has demonstrated remarkable response in lung cancer patients with tumors driven by oncogenic KRASG12C mutation. However, recently published clinical data identified acquired mutations in RAS and other genomic alterations as potential mechanisms… read more here.
Keywords: ras activity; lu65 amgr; resistance; pi3k signaling ... See more keywords