Linear ubiquitination modification of NR6A1 by LUBAC inhibits RIPK3 kinase activity and attenuates apoptosis of vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23091
Abstract: Nuclear receptor subfamily 6 group A member 1 (NR6A1) is involved in promoting the apoptotic process of vascular smooth muscle cells (VSMCs) which is a critical process involved in atherosclerosis, but the action mechanism remains… read more here.
Keywords: lubac; apoptosis; muscle cells; vascular smooth ... See more keywords
LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α
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DOI: 10.1038/s41389-024-00508-3
Abstract: Hypoxia-inducible factor 1 (HIF1) is critically important for driving angiogenesis and tumorigenesis. Linear ubiquitin chain assembly complex (LUBAC), the only known ubiquitin ligase capable of catalyzing protein linear ubiquitination to date, is implicated in cell… read more here.
Keywords: lung cancer; tumorigenesis; linear ubiquitination; lubac ... See more keywords
Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy
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DOI: 10.3389/fimmu.2021.635475
Abstract: Nuclear dot protein 52 kDa (NDP52, also known as CALCOCO2) functions as a selective autophagy receptor. The linear ubiquitin chain assembly complex (LUBAC) specifically generates the N-terminal Met1-linked linear ubiquitin chain, and regulates innate immune… read more here.
Keywords: lubac; ndp52 lubac; immune responses; ndp52 ... See more keywords