Genetic variation of staphylococcal LukAB toxin determines receptor tropism.
Sign Up to like & getrecommendations! Published in 2021 at "Nature microbiology"
DOI: 10.1038/s41564-021-00890-3
Abstract: Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in the coding sequences of core virulence factors. Whether these alterations affect functionality is poorly understood. Here, we studied the… read more here.
Keywords: variation staphylococcal; lukab; lukab toxin; toxin ... See more keywords
#31: Children with Invasive S. aureus Infection Produce Broadly Neutralizing Antibodies Against Distantly Related Variants of the Cytotoxin LukAB
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piab031.024
Abstract: Staphylococcus aureus is the most common invasive bacterial pathogen in children, and novel targets of intervention are urgently needed. The two-component leukotoxin, LukAB, is critical for S. aureus targeting and killing of human neutrophils and… read more here.
Keywords: invasive aureus; lukab; related variants; infection ... See more keywords
Serologic Detection of Antibodies Targeting the Leukocidin LukAB Strongly Predicts Staphylococcus aureus in Children With Invasive Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piy017
Abstract: BACKGROUND Staphylococcus aureus is among the most commonly identified causes of invasive bacterial infection in children; however, reliable results from cultures of sterile-site samples often cannot be obtained, which necessitates prescription of a broad empiric… read more here.
Keywords: aureus infection; phase; staphylococcus aureus; lukab ... See more keywords
Exploiting species specificity to understand the tropism of a human-specific toxin
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DOI: 10.1126/sciadv.aax7515
Abstract: Overcoming the species specificity of the MRSA toxin LukAB with a novel mouse model establishes a role for LukAB in vivo. Many pathogens produce virulence factors that are specific toward their natural host. Clinically relevant… read more here.
Keywords: species specificity; lukab; cd11b; toxin ... See more keywords