Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Toxicology"
DOI: 10.1177/1091581820951098
Abstract: Many potential drugs for treatment of neurodegenerative diseases, particularly antisense oligonucleotides (ASOs), are administered via lumbar intrathecal injection, because these drugs do not cross the blood–brain barrier. Intrathecal injection is a well-established method in cynomolgus… read more here.
Keywords: procedure related; lumbar intrathecal; injection; spinal cord ... See more keywords
A new approach for leptomeningeal metastases: chemotherapy administered through lumbar intrathecal port.
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DOI: 10.1590/0004-282x-anp-2020-0554
Abstract: BACKGROUND Intrathecal chemotherapy is a local therapeutic modality used for treatment of leptomeningeal metastases. However, the techniques currently used, i.e. repeated lumbar puncture and Ommaya reservoir, have certain disadvantages. Lumbar intrathecal port (LIP) placement is… read more here.
Keywords: chemotherapy; intrathecal port; intrathecal chemotherapy; leptomeningeal metastases ... See more keywords
Near-resolution of persistent idiopathic facial pain with low-dose lumbar intrathecal ziconotide: a case report
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DOI: 10.2147/jpr.s193746
Abstract: Purpose Persistent idiopathic facial pain (PIFP) is a poorly defined and debilitating chronic pain state with a challenging and often inadequate treatment course. This is the first case report identifying the novel use of low-dose… read more here.
Keywords: resolution; pain; ziconotide; lumbar intrathecal ... See more keywords