Articles with "lumefantrine" as a keyword



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Chiral Method by Normal Phase HPLC–UV for Quantitation of Lumefantrine Enantiomers in Tablet Formulations

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Published in 2019 at "Chromatographia"

DOI: 10.1007/s10337-019-03811-z

Abstract: Evaluating lumefantrine enantioselectivity and properly quantifying its enantiomers is essential for a deeper understanding of the impact of the enantioselectivity in the pharmacodynamic and pharmacokinetic properties of the drug. For this, a chiral chromatographic method… read more here.

Keywords: phase; enantiomers tablet; lumefantrine; method ... See more keywords
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Effects of the antimalarial Lumefantrine on Lemna minor, Raphidocelis subcapitata and Chlorella vulgaris.

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Published in 2021 at "Environmental toxicology and pharmacology"

DOI: 10.1016/j.etap.2021.103635

Abstract: Lumefantrine is used to treat uncomplicated malaria caused by pure or mixed Plasmodium falciparum infections and as a prophylactic against recrudescence following artemether therapy. However, the pharmaceutical is released into the aquatic environment from industrial… read more here.

Keywords: growth; lumefantrine; raphidocelis subcapitata; chlorella vulgaris ... See more keywords
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Strong correlation of lumefantrine concentrations in capillary and venous plasma from malaria patients

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Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0202082

Abstract: Background Lumefantrine is a long-acting antimalarial drug with an elimination half-life of over 3 days and protein binding of 99 percent. Correlation of lumefantrine concentrations from capillary plasma via fingerprick (Cc) versus venous plasma (Cv)… read more here.

Keywords: plasma; capillary venous; lumefantrine; correlation lumefantrine ... See more keywords
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THE DEVELOPMENT AND VALIDATION OF A FAST STABILITY INDICATING RP-HPLC METHOD FOR QUANTIFICATION OF LUMEFANTRINE AND ITS ORGANIC IMPURITIES USING CENTRAL COMPOSITE EXPERIMENTAL DESIGN

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Published in 2023 at "International Journal of Applied Pharmaceutics"

DOI: 10.22159/ijap.2023v15i3.47698

Abstract: Objective: The objective of the present study was to develop and validate a stability indicating RP-HPLC method for Lumefantrine (LF) and its organic impurities using a central composite design (CCD). Methods: A specific, simple quality… read more here.

Keywords: lumefantrine; organic impurities; stability indicating; indicating hplc ... See more keywords
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Comparison of classical, stealth and super-stealth liposomes for intravenous delivery of lumefantrine: Formulation, characterization and pharmacodynamic study

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Published in 2020 at "Tropical Journal of Pharmaceutical Research"

DOI: 10.4314/tjpr.v19i11.1

Abstract: Purpose: To develop and compare classical liposomes (CL), stealth liposomes (SL) and super-stealth liposomes (SSL) encapsulating lumefantrine for intravenous administration. Method: CL, SL or SSL were prepared by thin-layer evaporation method and evaluated for particle… read more here.

Keywords: stealth liposomes; lumefantrine; stealth; pharmacodynamic study ... See more keywords